Xin yixue (Aug 2022)

Characteristics and drug resistance of 289 pathogenic strains in nosocomial infection

  • Fu Jinxian, Yu Guangchao, Pi Sainan, Chen Youpeng

DOI
https://doi.org/10.3969/j.issn.0253-9802.2022.08.011
Journal volume & issue
Vol. 53, no. 8
pp. 592 – 596

Abstract

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Objective To analyze the distribution and drug resistance of pathogens in nosocomial infection （NI） among patients in general hospital. Methods 289 pathogenic strains in NI were screened from hospitalized patients. The distribution, classification, and drug resistance were analyzed. Results Among 289 pathogenic strains, 74.05% of them were gram-negative bacilli, 16.96% were gram-positive cocci and 8.30% were fungi. Moreover, 55.10% of gram-positive cocci and 54.21% of gram-negative bacilli were multidrug-resistant organisms （MDRO）, with no statistical difference between two strains （P > 0.05）. There were 95 strains of Acinetobacter baumannii （ABA, 32.87%）, 40 strains of Klebsiella pneumoniae （KPN, 13.84%） and 34 strains of Pseudomonas aeruginosa （PAE, 11.76%） for the common pathogens in NI. The incidence rate of KPN in 2019 was increased more than 4 times compared with that in 2016. The specimens were mainly taken from the lower respiratory sputum, blood, and urine. Most pathogens were detected from ICU, Department of Neurosurgery, Department of Respiratory Medicine and Department of Hematology. Cefoperazone-sulbactam, minocycline and tigecycline exerted better effect on ABA. KPN was less resistant to both amikacin and tigecycline. PAE was also less resistant to aminoglycosides, ceftazidime, cefoperazone-sulbactam and cefepime. Conclusions Gram-negative bacilli are the major pathogens in NI in general hospital, especially ABA, KPN and PAE. These pathogens yield severe multidrug resistance. Multidrug-resistant gram-negative bacilli should be considered for empirical medication.

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