Медицинская иммунология (Jul 2014)

HIGH LEVEL OF IL -1 RECEPTOR ANTAGONIST AS A LETHALITY FACTOR IN PATIENTS WITH SURGICAL SEPSIS

  • V. V. Grebenyuk,
  • G. A. Makarova,
  • N. V. Yusan

DOI
https://doi.org/10.15789/1563-0625-2009-2-3-287-288
Journal volume & issue
Vol. 11, no. 2-3
pp. 287 – 288

Abstract

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Absract. The data are presented that concern the levels of IL-1 receptor antagonist (IL-1 Ra) in blood serum of twenty-five patients with severe surgical sepsis. Sixteen patients recovered from the condition, whereas lethal outcome was registered in nine cases. The study was performed by means of immunoassay, using «IFA-Best IL-1 Ra» kits supplied by the Vector-Best firm. Only three patients showed IL-1 Ra contents within normal limits, whereas others exhibited marked increase in IL-1 Ra levels, up to a mean of 2443.656±382.85 pg/ml (normal range, 50 to 1000 pg/ml).

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