Relative factors to sarcopenia in type 2 diabetes patients

Abstract

Objective To investigate the occurrence of sarcopenia in the patients with type 2 diabetes mellitus (T2DM) and the relationship of its related factors. Methods Cross-sectional survey was adopted to select 450 T2DM patients (256 males and 194 females) who were hospitalized in the Department of Endocrinology and Metabolism of Affiliated Hospital of Guizhou Medical University from April 2015 to November 2015. Their general conditions, blood indexes, and body composition indexes were investigated. According to the diagnostic criteria of the Asian Working Group on Sarcopenia, sarcopenia was diagnosed with relative skeletal muscle mass index (RASM) described as appendicular muscle mass divided by height square, with male < 7.00 kg/m2 and female < 5.40 kg/m2. Results There were 64 patients suffering from sarcopenia, with a total prevalence rate of 14.22%. The prevalence rate of males and females was 19.14% and 7.73%, respectively (P < 0.05). The age was older and creatinine level was higher in the sarcopenia group than the non-sarcopenia group (P < 0.05). The body mass index (BMI), android/gynoid (A/G) fat ratio and triglyceride level were significantly lower in the sarcopenia group compared with the non-sarcopenia group (P < 0.05). Multivariate logistic regression analysis showed that after correcting confounding factors including age and gender, smoking (OR=2.156, 95%CI: 1.226~3.790) was a risk factor, while BMI (OR=0.529, 95%CI: 0.448~0.625) and A/G fat ratio (OR=0.007, 95%CI: 0.001~0.046) were protective factors for sarcopenia. Conclusion Smoking is a risk factor for sarcopenia in type 2 diabetic patients. BMI and A/G fat ratio may be protective factors for sarcopenia.

Keywords

• type 2 diabetes mellitus
• sarcopenia
• smoking
• body mass index
• android/gynoid fat ratio