Nature Communications (Jun 2022)
Endowing universal CAR T-cell with immune-evasive properties using TALEN-gene editing
- Sumin Jo,
- Shipra Das,
- Alan Williams,
- Anne-Sophie Chretien,
- Thomas Pagliardini,
- Aude Le Roy,
- Jorge Postigo Fernandez,
- Diane Le Clerre,
- Billal Jahangiri,
- Isabelle Chion-Sotinel,
- Sandra Rozlan,
- Emilie Dessez,
- Agnes Gouble,
- Mathilde Dusséaux,
- Roman Galetto,
- Aymeric Duclert,
- Emanuela Marcenaro,
- Raynier Devillier,
- Daniel Olive,
- Philippe Duchateau,
- Laurent Poirot,
- Julien Valton
Affiliations
- Sumin Jo
- Cellectis, Inc.
- Shipra Das
- Cellectis, Inc.
- Alan Williams
- Cellectis, Inc.
- Anne-Sophie Chretien
- Institut Paoli-Calmettes; Aix-Marseille Université UM105
- Thomas Pagliardini
- Institut Paoli-Calmettes; Aix-Marseille Université UM105
- Aude Le Roy
- Institut Paoli-Calmettes; Aix-Marseille Université UM105
- Jorge Postigo Fernandez
- Cellectis, Inc.
- Diane Le Clerre
- Cellectis, 8 rue de la Croix Jarry
- Billal Jahangiri
- Cellectis, Inc.
- Isabelle Chion-Sotinel
- Cellectis, 8 rue de la Croix Jarry
- Sandra Rozlan
- Cellectis, 8 rue de la Croix Jarry
- Emilie Dessez
- Cellectis, 8 rue de la Croix Jarry
- Agnes Gouble
- Cellectis, 8 rue de la Croix Jarry
- Mathilde Dusséaux
- Cellectis, 8 rue de la Croix Jarry
- Roman Galetto
- Cellectis, 8 rue de la Croix Jarry
- Aymeric Duclert
- Cellectis, 8 rue de la Croix Jarry
- Emanuela Marcenaro
- Department of Experimental Medicine, University of Genova
- Raynier Devillier
- Institut Paoli-Calmettes; Aix-Marseille Université UM105
- Daniel Olive
- Institut Paoli-Calmettes; Aix-Marseille Université UM105
- Philippe Duchateau
- Cellectis, 8 rue de la Croix Jarry
- Laurent Poirot
- Cellectis, Inc.
- Julien Valton
- Cellectis, Inc.
- DOI
- https://doi.org/10.1038/s41467-022-30896-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Host versus graft reaction is a major impediment to CAR-T cell immune therapy in allogeneic settings. Authors show here that CAR-T cells, engineered to be deficient in MHC I expression but to express the NK inhibitor HLA-E, are resistant to destruction by both T and NK cells of the host.
