Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome

Luke Y.C. Chen; Catherine M. Biggs; Shahin Jamal; Sophie Stukas; Cheryl L. Wellington; Mypinder S. Sekhon

Cell Reports Medicine (May 2021)

Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome

Luke Y.C. Chen,
Catherine M. Biggs,
Shahin Jamal,
Sophie Stukas,
Cheryl L. Wellington,
Mypinder S. Sekhon

Affiliations

Luke Y.C. Chen: Division of Hematology, University of British Columbia, Vancouver, BC V5Z1M9, Canada; Centre for Health Education Scholarship, University of British Columbia, Vancouver, BC V6T1Z3, Canada; Corresponding author
Catherine M. Biggs: Division of Allergy and Immunology, University of British Columbia, Vancouver, BC V5Z1M9, Canada
Shahin Jamal: Division of Rheumatology, University of British Columbia, Vancouver, BC V5Z1M9, Canada
Sophie Stukas: Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V5Z1M9, Canada; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T1Z3, Canada
Cheryl L. Wellington: Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V5Z1M9, Canada; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T1Z3, Canada
Mypinder S. Sekhon: Division of Critical Care Medicine, University of British Columbia, Vancouver, BC V5Z1M9, Canada

Journal volume & issue: Vol. 2, no. 5
p. 100269

Abstract

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Summary: Data suggest that interleukin (IL)-6 blockade could reduce mortality in severe COVID-19, yet IL-6 is only modestly elevated in most patients. Chen et al. describe the role of soluble interleukin-6 receptor (sIL-6R) in IL-6 trans-signaling and how understanding the IL-6:sIL-6R axis might help define and treat COVID-19 cytokine storm syndrome.

Published in Cell Reports Medicine

ISSN: 2666-3791 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General)
Website: https://www.cell.com/cell-reports-medicine

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Abstract

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