Nature Communications (Jun 2020)

Rational design of aptamer switches with programmable pH response

  • Ian A. P. Thompson,
  • Liwei Zheng,
  • Michael Eisenstein,
  • H. Tom Soh

DOI
https://doi.org/10.1038/s41467-020-16808-2
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 7

Abstract

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Previous design strategies for pH sensitive aptamers were not readily tunable across pH ranges. Here the authors present a general method to convert aptamers into pH-responsive switches using two orthogonal motifs.