Nature Communications (May 2022)
Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes
- Chunyan Wang,
- Emma L. Hesketh,
- Tatiana M. Shamorkina,
- Wentao Li,
- Peter J. Franken,
- Dubravka Drabek,
- Rien van Haperen,
- Sarah Townend,
- Frank J. M. van Kuppeveld,
- Frank Grosveld,
- Neil A. Ranson,
- Joost Snijder,
- Raoul J. de Groot,
- Daniel L. Hurdiss,
- Berend-Jan Bosch
Affiliations
- Chunyan Wang
- Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University
- Emma L. Hesketh
- Astbury Centre Structural Molecular Biology, School Molecular and Cellular Biology, Faculty Biological Sciences, University of Leeds
- Tatiana M. Shamorkina
- Biomolecular Mass Spectrometry & Proteomics, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University
- Wentao Li
- Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University
- Peter J. Franken
- Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University
- Dubravka Drabek
- Department of Cell Biology, Erasmus Medical Center
- Rien van Haperen
- Department of Cell Biology, Erasmus Medical Center
- Sarah Townend
- Astbury Centre Structural Molecular Biology, School Molecular and Cellular Biology, Faculty Biological Sciences, University of Leeds
- Frank J. M. van Kuppeveld
- Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University
- Frank Grosveld
- Department of Cell Biology, Erasmus Medical Center
- Neil A. Ranson
- Astbury Centre Structural Molecular Biology, School Molecular and Cellular Biology, Faculty Biological Sciences, University of Leeds
- Joost Snijder
- Biomolecular Mass Spectrometry & Proteomics, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University
- Raoul J. de Groot
- Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University
- Daniel L. Hurdiss
- Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University
- Berend-Jan Bosch
- Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University
- DOI
- https://doi.org/10.1038/s41467-022-30658-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Human coronavirus OC43 causes respiratory disease and is maintained in the human population through recurring infections. Here, by extensive structural analyses, the authors provide insights into the binding sites and breadth of neutralizing antibodies against this endemic coronavirus.
