Variant antigen diversity in Trypanosoma vivax is not driven by recombination

Sara Silva Pereira; Kayo J. G. de Almeida Castilho Neto; Craig W. Duffy; Peter Richards; Harry Noyes; Moses Ogugo; Marcos Rogério André; Zakaria Bengaly; Steve Kemp; Marta M. G. Teixeira; Rosangela Z. Machado; Andrew P. Jackson

doi:10.1038/s41467-020-14575-8

Nature Communications (Feb 2020)

Variant antigen diversity in Trypanosoma vivax is not driven by recombination

Sara Silva Pereira,
Kayo J. G. de Almeida Castilho Neto,
Craig W. Duffy,
Peter Richards,
Harry Noyes,
Moses Ogugo,
Marcos Rogério André,
Zakaria Bengaly,
Steve Kemp,
Marta M. G. Teixeira,
Rosangela Z. Machado,
Andrew P. Jackson

Affiliations

Sara Silva Pereira: Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool
Kayo J. G. de Almeida Castilho Neto: Department of Veterinary Pathology, Faculty of Agrarian and Veterinary Sciences, São Paulo State University (UNESP)
Craig W. Duffy: Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool
Peter Richards: Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool
Harry Noyes: Institute of Integrative Biology, University of Liverpool
Moses Ogugo: Livestock Genetic Programme, International Livestock Research Institute
Marcos Rogério André: Department of Veterinary Pathology, Faculty of Agrarian and Veterinary Sciences, São Paulo State University (UNESP)
Zakaria Bengaly: International Research Centre for Livestock Development in the Sub-humid Zone (CIRDES)
Steve Kemp: Livestock Genetic Programme, International Livestock Research Institute
Marta M. G. Teixeira: Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo
Rosangela Z. Machado: Department of Veterinary Pathology, Faculty of Agrarian and Veterinary Sciences, São Paulo State University (UNESP)
Andrew P. Jackson: Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool

DOI: https://doi.org/10.1038/s41467-020-14575-8
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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Trypanosoma rely on variant surface glycoprotein (VSG) to escape host immunity, but mechanisms generating antigenic diversity of VSG are poorly understood. Here, Silva-Pereira et al. show that T. vivax has a limited antigenic repertoire compared to T. brucei and that recombination plays little role in diversifying T. vivax VSG sequences.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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