BMC Infectious Diseases (Apr 2009)

Risk and prognostic significance of tuberculosis in patients from The TREAT Asia HIV Observational Database

  • Sungkanuparph Somnuek,
  • Sirisanthana Thira,
  • Vonthanak Saphonn,
  • Phanuphak Praphan,
  • Chen Yi-Ming A,
  • Pujari Sanjay,
  • Merati Tuti,
  • Kumarasamy Nagalingeswaran,
  • Kiertiburanakul Sasisopin,
  • Lim Poh,
  • Li Patrick CK,
  • Elliott Julian,
  • Zhou Jialun,
  • Lee Christopher KC,
  • Kamarulzaman Adeeba,
  • Oka Shinichi,
  • Zhang Fujie,
  • Tau Goa,
  • Ditangco Rossana

DOI
https://doi.org/10.1186/1471-2334-9-46
Journal volume & issue
Vol. 9, no. 1
p. 46

Abstract

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Abstract Background To assess the risk and the prognostic significance of tuberculosis (TB) diagnosis in patients from The TREAT Asia HIV Observational Database, a multi-centre prospective cohort of HIV-infected patients receiving HIV care in the Asia-Pacific region. Methods The risk of TB diagnosis after recruitment was assessed in patients with prospective follow-up. TB diagnosis was fitted as a time-dependent variable in assessing overall survival. Results At baseline, 22% of patients were diagnosed with TB. TB incidence was 1.98 per 100 person-years during follow up, with predictors including younger age, lower recent CD4 count, duration of antiretroviral treatment, and living in high TB burden countries. Among 3279 patients during 6968 person-years, 142 died (2.04 per 100 person-years). Compared to patients with CDC category A or B illness only, mortality was marginally higher in patients with single Non-TB AIDS defining illness (ADI), or TB only (adjusted HR 1.35, p = 0.173) and highest in patients with multiple non-TB AIDS or both TB and other ADI (adjusted HR 2.21, p Conclusion The risk of TB diagnosis was associated with increasing immunodeficiency and partly reduced by antiretroviral treatment. The prognosis of developing TB appeared to be similar to that following a diagnosis of other non-TB ADI.