Influence of diffuse oxygen supply on physiological effects in migrants in plateau: a study based on a new accommodation cabin

Abstract

Objective To determine the effects of diffuse oxygen inhalation on hypoxia stress, blood oxygen saturation and human metabolic process in migrants in plateau, and to illustrate the anti-hypoxia effect of a new oxygen supply mode and its possible molecular mechanism. Methods Ten workers who had migrated to a plateau at an altitude of 3 540 m for more than 1 year were recruited as the subjects. They were asked to breathe oxygen in a newly developed accommodation cabin with diffuse oxygen supply for 3 consecutive days, 2 h per day. Their physiological indexes, blood routine indexes and plasma metabolic profiles before and after oxygen intake were measured and compared. Results ① The oxygen concentration was (22.85±0.36)% on the first day, (22.52±0.76)% on the second day and (22.57±1.05)% on the third day during the diffusion oxygen inhalation in the accommodation cabin. ②The oxygen saturation level and pulse rate were significantly increased after oxygen inhalation in the subjects (P 0.05). ③ There were 44 metabolites significantly changed (VIP>1, P 0.05, -log10(P)>1.3]. Conclusion Oxygen inhalation via diffuse oxygen supply can effectively improve the capacity of cardiopulmonary oxygen supply, and alleviate the impact of hypoxia and cold environment on human metabolism.

Keywords

• diffuse oxygen
• plateau personnel
• accommodation cabin
• liquid chromatography-mass spectrometry
• metabonomics