Knock out of the NADPH oxidase Nox4 has no impact on life span in mice
Flavia Rezende,
Christoph Schürmann,
Susanne Schütz,
Sabine Harenkamp,
Eva Herrmann,
Michael Seimetz,
Norbert Weißmann,
Katrin Schröder
Affiliations
Flavia Rezende
Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany
Christoph Schürmann
Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany
Susanne Schütz
Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany
Sabine Harenkamp
Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany
Eva Herrmann
Instituts für Biostatistik und Mathematische Modellierung, Goethe-University, Frankfurt, Germany
Michael Seimetz
Justus-Liebig University, Giessen, German Center for Lung Research (DZL), Germany; Excellence Cluster Cardiovascular and Pulmonary System (ECCPS), Germany
Norbert Weißmann
Justus-Liebig University, Giessen, German Center for Lung Research (DZL), Germany; Excellence Cluster Cardiovascular and Pulmonary System (ECCPS), Germany
Katrin Schröder
Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany; Excellence Cluster Cardiovascular and Pulmonary System (ECCPS), Germany; German Center for Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany; Correspondence to: Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der Goethe-Universität, Theodor-Stern Kai 7, 60590 Frankfurt, Germany
The free radical theory of aging suggests reactive oxygen species as a main reason for accumulation of damage events eventually leading to aging. Nox4, a member of the family of NADPH oxidases constitutively produces ROS and therefore has the potential to be a main driver of aging. Herein we analyzed the life span of Nox4 deficient mice and found no difference when compared to their wildtype littermates. Accordingly neither Tert expression nor telomere length was different in cells isolated from those animals. In fact, Nox4 mRNA expression in lungs of wildtype mice dropped with age. We conclude that Nox4 has no influence on lifespan of healthy mice. Keywords: Nox4, Aging
