Case Reports in Oncology (Jul 2021)
Controlling Major Portal Vein Invasion Progression during Lenvatinib Treatment by Carbon-Ion Radiotherapy in Patients with Advanced Hepatocellular Carcinoma
- Ryoi Yoshida,
- Keisuke Koroki,
- Hirokazu Makishima,
- Sadahisa Ogasawara,
- Takamasa Ishino,
- Keita Ogawa,
- Miyuki Nakagawa,
- Kisako Fujiwara,
- Hidemi Unozawa,
- Terunao Iwanaga,
- Naoto Fujita,
- Takafumi Sakuma,
- Hiroaki Kanzaki,
- Kazufumi Kobayashi,
- Naoya Kanogawa,
- Soichiro Kiyono,
- Masato Nakamura,
- Takayuki Kondo,
- Tomoko Saito,
- Ryo Nakagawa,
- Eiichiro Suzuki,
- Yoshihiko Ooka,
- Shingo Nakamoto,
- Akinobu Tawada,
- Tetsuhiro Chiba,
- Makoto Arai,
- Takashi Kaneko,
- Masaru Wakatsuki,
- Jun Kato,
- Hiroshi Tsuji,
- Naoya Kato
Affiliations
- Ryoi Yoshida
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Keisuke Koroki
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Hirokazu Makishima
- National Institutes for Quantum and Radiological Science and Technology QST Hospital, Chiba, Japan
- Sadahisa Ogasawara
- ORCiD
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Takamasa Ishino
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Keita Ogawa
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Miyuki Nakagawa
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Kisako Fujiwara
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Hidemi Unozawa
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Terunao Iwanaga
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Naoto Fujita
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Takafumi Sakuma
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Hiroaki Kanzaki
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Kazufumi Kobayashi
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Naoya Kanogawa
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Soichiro Kiyono
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Masato Nakamura
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Takayuki Kondo
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Tomoko Saito
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Ryo Nakagawa
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Eiichiro Suzuki
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Yoshihiko Ooka
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Shingo Nakamoto
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Akinobu Tawada
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Tetsuhiro Chiba
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Makoto Arai
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Takashi Kaneko
- National Institutes for Quantum and Radiological Science and Technology QST Hospital, Chiba, Japan
- Masaru Wakatsuki
- National Institutes for Quantum and Radiological Science and Technology QST Hospital, Chiba, Japan
- Jun Kato
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Hiroshi Tsuji
- National Institutes for Quantum and Radiological Science and Technology QST Hospital, Chiba, Japan
- Naoya Kato
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
- DOI
- https://doi.org/10.1159/000517440
- Journal volume & issue
-
Vol. 14,
no. 2
pp. 1103 – 1110
Abstract
Macrovascular invasion (MVI), including portal vein tumor thrombosis (PVTT), is strongly associated with poor prognosis in patients with hepatocellular carcinoma (HCC). While recommended standard treatment for patients with advanced HCC is systemic therapy, various treatment approaches, including resection, transarterial chemoembolization, and radiation, have been empirically suggested to improve prognosis by eliminating or controlling MVI. Herein, we report our experience of a case with advanced HCC where MVI was controlled by carbon-ion radiotherapy (CIRT) while on systemic therapy, resulting in a prolonged survival. A female patient with HCC in her early 60s had multiple intrahepatic lesions (maximum 60 mm in diameter) with PVTT. The PVTT of this patient had reached the main trunk of the portal vein despite the use of lenvatinib. The other intrahepatic lesions of the patient, except PVTT, had been controlled by lenvatinib. Therefore, hoping to control PVTT, we attempted CIRT. The patient resumed lenvatinib therapy after the irradiation. During lenvatinib re-treatment, no evident progression of PVTT was observed in the patient.
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