Nature Communications (Feb 2016)

Structure of the poly-C9 component of the complement membrane attack complex

  • Natalya V. Dudkina,
  • Bradley A. Spicer,
  • Cyril F. Reboul,
  • Paul J. Conroy,
  • Natalya Lukoyanova,
  • Hans Elmlund,
  • Ruby H. P. Law,
  • Susan M. Ekkel,
  • Stephanie C. Kondos,
  • Robert J. A. Goode,
  • Georg Ramm,
  • James C. Whisstock,
  • Helen R. Saibil,
  • Michelle A. Dunstone

DOI
https://doi.org/10.1038/ncomms10588
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 6

Abstract

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The membrane attack complex is a heteromeric assembly of complement proteins where multiple copies of C9 are recruited by the C5b678 complex to form lytic pores in pathogen membranes. Here the authors present the structure of a soluble pore-like form of the C9 component that reveals details of the oligomerization interfaces.