The blood–brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates—Evidence from in vivo neuroimaging studies

Arnar Astradsson; Bruce G. Jenkins; Ji-Kyung Choi; Penelope J. Hallett; Michele A. Levesque; Jack S. McDowell; Anna-Liisa Brownell; Roger D. Spealman; Ole Isacson

Neurobiology of Disease (Sep 2009)

The blood–brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates—Evidence from in vivo neuroimaging studies

Arnar Astradsson,
Bruce G. Jenkins,
Ji-Kyung Choi,
Penelope J. Hallett,
Michele A. Levesque,
Jack S. McDowell,
Anna-Liisa Brownell,
Roger D. Spealman,
Ole Isacson

Affiliations

Arnar Astradsson: Harvard University and McLean Hospital, NINDS Udall Parkinson's Disease Research Center of Excellence, Belmont, MA, USA; New England Primate Research Center, Harvard Medical School, Southborough, MA, USA
Bruce G. Jenkins: Harvard University and McLean Hospital, NINDS Udall Parkinson's Disease Research Center of Excellence, Belmont, MA, USA; Massachusetts General Hospital (MGH) Nuclear Magnetic Resonance Center, Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, USA
Ji-Kyung Choi: Massachusetts General Hospital (MGH) Nuclear Magnetic Resonance Center, Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, USA
Penelope J. Hallett: Harvard University and McLean Hospital, NINDS Udall Parkinson's Disease Research Center of Excellence, Belmont, MA, USA; New England Primate Research Center, Harvard Medical School, Southborough, MA, USA
Michele A. Levesque: Harvard University and McLean Hospital, NINDS Udall Parkinson's Disease Research Center of Excellence, Belmont, MA, USA; New England Primate Research Center, Harvard Medical School, Southborough, MA, USA
Jack S. McDowell: Harvard University and McLean Hospital, NINDS Udall Parkinson's Disease Research Center of Excellence, Belmont, MA, USA; New England Primate Research Center, Harvard Medical School, Southborough, MA, USA
Anna-Liisa Brownell: Harvard University and McLean Hospital, NINDS Udall Parkinson's Disease Research Center of Excellence, Belmont, MA, USA; MGH Positron Emission Tomography Center, Massachusetts General Hospital, Boston, MA, USA
Roger D. Spealman: Harvard University and McLean Hospital, NINDS Udall Parkinson's Disease Research Center of Excellence, Belmont, MA, USA; New England Primate Research Center, Harvard Medical School, Southborough, MA, USA
Ole Isacson: Harvard University and McLean Hospital, NINDS Udall Parkinson's Disease Research Center of Excellence, Belmont, MA, USA; New England Primate Research Center, Harvard Medical School, Southborough, MA, USA; Corresponding author. Center for Neuroregeneration Research, McLean Hospital/Harvard Medical School, MRC 130, 115 Mill St, Belmont, MA 02478, USA.

Journal volume & issue: Vol. 35, no. 3
pp. 348 – 351

Abstract

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It has been suggested, based on rodent studies, that levodopa (l-dopa) induced dyskinesia is associated with a disrupted blood–brain barrier (BBB). We have investigated BBB integrity with in vivo neuroimaging techniques in six 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesioned primates exhibiting l-dopa-induced dyskinesia. Magnetic resonance imaging (MRI) performed before and after injection of Gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) revealed an intact BBB in the basal ganglia showing that l-dopa-induced dyskinesia is not associated with a disrupted BBB in this model.

Published in Neurobiology of Disease

ISSN: 0969-9961 (Print); 1095-953X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neurobiology-of-disease

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