Nature Communications (Feb 2021)

A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

  • Juliette Coignard,
  • Michael Lush,
  • Jonathan Beesley,
  • Tracy A. O’Mara,
  • Joe Dennis,
  • Jonathan P. Tyrer,
  • Daniel R. Barnes,
  • Lesley McGuffog,
  • Goska Leslie,
  • Manjeet K. Bolla,
  • Muriel A. Adank,
  • Simona Agata,
  • Thomas Ahearn,
  • Kristiina Aittomäki,
  • Irene L. Andrulis,
  • Hoda Anton-Culver,
  • Volker Arndt,
  • Norbert Arnold,
  • Kristan J. Aronson,
  • Banu K. Arun,
  • Annelie Augustinsson,
  • Jacopo Azzollini,
  • Daniel Barrowdale,
  • Caroline Baynes,
  • Heko Becher,
  • Marina Bermisheva,
  • Leslie Bernstein,
  • Katarzyna Białkowska,
  • Carl Blomqvist,
  • Stig E. Bojesen,
  • Bernardo Bonanni,
  • Ake Borg,
  • Hiltrud Brauch,
  • Hermann Brenner,
  • Barbara Burwinkel,
  • Saundra S. Buys,
  • Trinidad Caldés,
  • Maria A. Caligo,
  • Daniele Campa,
  • Brian D. Carter,
  • Jose E. Castelao,
  • Jenny Chang-Claude,
  • Stephen J. Chanock,
  • Wendy K. Chung,
  • Kathleen B. M. Claes,
  • Christine L. Clarke,
  • GEMO Study Collaborators,
  • EMBRACE Collaborators,
  • J. Margriet Collée,
  • Don M. Conroy,
  • Kamila Czene,
  • Mary B. Daly,
  • Peter Devilee,
  • Orland Diez,
  • Yuan Chun Ding,
  • Susan M. Domchek,
  • Thilo Dörk,
  • Isabel dos-Santos-Silva,
  • Alison M. Dunning,
  • Miriam Dwek,
  • Diana M. Eccles,
  • A. Heather Eliassen,
  • Christoph Engel,
  • Mikael Eriksson,
  • D. Gareth Evans,
  • Peter A. Fasching,
  • Henrik Flyger,
  • Florentia Fostira,
  • Eitan Friedman,
  • Lin Fritschi,
  • Debra Frost,
  • Manuela Gago-Dominguez,
  • Susan M. Gapstur,
  • Judy Garber,
  • Vanesa Garcia-Barberan,
  • Montserrat García-Closas,
  • José A. García-Sáenz,
  • Mia M. Gaudet,
  • Simon A. Gayther,
  • Andrea Gehrig,
  • Vassilios Georgoulias,
  • Graham G. Giles,
  • Andrew K. Godwin,
  • Mark S. Goldberg,
  • David E. Goldgar,
  • Anna González-Neira,
  • Mark H. Greene,
  • Pascal Guénel,
  • Lothar Haeberle,
  • Eric Hahnen,
  • Christopher A. Haiman,
  • Niclas Håkansson,
  • Per Hall,
  • Ute Hamann,
  • Patricia A. Harrington,
  • Steven N. Hart,
  • Wei He,
  • Frans B. L. Hogervorst,
  • Antoinette Hollestelle,
  • John L. Hopper,
  • Darling J. Horcasitas,
  • Peter J. Hulick,
  • David J. Hunter,
  • Evgeny N. Imyanitov,
  • KConFab Investigators,
  • HEBON Investigators,
  • ABCTB Investigators,
  • Agnes Jager,
  • Anna Jakubowska,
  • Paul A. James,
  • Uffe Birk Jensen,
  • Esther M. John,
  • Michael E. Jones,
  • Rudolf Kaaks,
  • Pooja Middha Kapoor,
  • Beth Y. Karlan,
  • Renske Keeman,
  • Elza Khusnutdinova,
  • Johanna I. Kiiski,
  • Yon-Dschun Ko,
  • Veli-Matti Kosma,
  • Peter Kraft,
  • Allison W. Kurian,
  • Yael Laitman,
  • Diether Lambrechts,
  • Loic Le Marchand,
  • Jenny Lester,
  • Fabienne Lesueur,
  • Tricia Lindstrom,
  • Adria Lopez-Fernández,
  • Jennifer T. Loud,
  • Craig Luccarini,
  • Arto Mannermaa,
  • Siranoush Manoukian,
  • Sara Margolin,
  • John W. M. Martens,
  • Noura Mebirouk,
  • Alfons Meindl,
  • Austin Miller,
  • Roger L. Milne,
  • Marco Montagna,
  • Katherine L. Nathanson,
  • Susan L. Neuhausen,
  • Heli Nevanlinna,
  • Finn C. Nielsen,
  • Katie M. O’Brien,
  • Olufunmilayo I. Olopade,
  • Janet E. Olson,
  • Håkan Olsson,
  • Ana Osorio,
  • Laura Ottini,
  • Tjoung-Won Park-Simon,
  • Michael T. Parsons,
  • Inge Sokilde Pedersen,
  • Beth Peshkin,
  • Paolo Peterlongo,
  • Julian Peto,
  • Paul D. P. Pharoah,
  • Kelly-Anne Phillips,
  • Eric C. Polley,
  • Bruce Poppe,
  • Nadege Presneau,
  • Miquel Angel Pujana,
  • Kevin Punie,
  • Paolo Radice,
  • Johanna Rantala,
  • Muhammad U. Rashid,
  • Gad Rennert,
  • Hedy S. Rennert,
  • Mark Robson,
  • Atocha Romero,
  • Maria Rossing,
  • Emmanouil Saloustros,
  • Dale P. Sandler,
  • Regina Santella,
  • Maren T. Scheuner,
  • Marjanka K. Schmidt,
  • Gunnar Schmidt,
  • Christopher Scott,
  • Priyanka Sharma,
  • Penny Soucy,
  • Melissa C. Southey,
  • John J. Spinelli,
  • Zoe Steinsnyder,
  • Jennifer Stone,
  • Dominique Stoppa-Lyonnet,
  • Anthony Swerdlow,
  • Rulla M. Tamimi,
  • William J. Tapper,
  • Jack A. Taylor,
  • Mary Beth Terry,
  • Alex Teulé,
  • Darcy L. Thull,
  • Marc Tischkowitz,
  • Amanda E. Toland,
  • Diana Torres,
  • Alison H. Trainer,
  • Thérèse Truong,
  • Nadine Tung,
  • Celine M. Vachon,
  • Ana Vega,
  • Joseph Vijai,
  • Qin Wang,
  • Barbara Wappenschmidt,
  • Clarice R. Weinberg,
  • Jeffrey N. Weitzel,
  • Camilla Wendt,
  • Alicja Wolk,
  • Siddhartha Yadav,
  • Xiaohong R. Yang,
  • Drakoulis Yannoukakos,
  • Wei Zheng,
  • Argyrios Ziogas,
  • Kristin K. Zorn,
  • Sue K. Park,
  • Mads Thomassen,
  • Kenneth Offit,
  • Rita K. Schmutzler,
  • Fergus J. Couch,
  • Jacques Simard,
  • Georgia Chenevix-Trench,
  • Douglas F. Easton,
  • Nadine Andrieu,
  • Antonis C. Antoniou

DOI
https://doi.org/10.1038/s41467-020-20496-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 22

Abstract

Read online

Breast cancer risk for BRCA1/BRCA2 mutation carriers varies depending on other genetic factors. Here, the authors perform a case-only genome-wide association study and highlight novel loci associated with breast cancer risk for BRCA1/BRCA2 mutation carriers.