MODERN CONCEPTS OF SEPSIS PATHOGENESIS AND PERSPECTIVE APPROACH TO IT''S TREATMENT

Abstract

Over the past hundred years, understanding of the sepsis pathogenesis as well as approaches to its treatment has dramatically changed. Great importance is attached to circulating inflammatory mediators. The paper presents the modern concept of the sepsis pathogenesis, some types of extracorporeal therapy and describes the main hypotheses to explain the effectiveness or ineffectiveness of the therapy.

Keywords

• sepsis
• multiple organ failure
• pathogenesis
• cytokines
• extracorporeal haemocorrection
• hemofiltration
• sorption