Microbiome (Jun 2017)
Maternal inheritance of bifidobacterial communities and bifidophages in infants through vertical transmission
- Sabrina Duranti,
- Gabriele Andrea Lugli,
- Leonardo Mancabelli,
- Federica Armanini,
- Francesca Turroni,
- Kieran James,
- Pamela Ferretti,
- Valentina Gorfer,
- Chiara Ferrario,
- Christian Milani,
- Marta Mangifesta,
- Rosaria Anzalone,
- Moreno Zolfo,
- Alice Viappiani,
- Edoardo Pasolli,
- Ilaria Bariletti,
- Rosarita Canto,
- Rosanna Clementi,
- Marina Cologna,
- Tiziana Crifò,
- Giuseppina Cusumano,
- Sabina Fedi,
- Stefania Gottardi,
- Claudia Innamorati,
- Caterina Masè,
- Daniela Postai,
- Daniela Savoi,
- Massimo Soffiati,
- Saverio Tateo,
- Anna Pedrotti,
- Nicola Segata,
- Douwe van Sinderen,
- Marco Ventura
Affiliations
- Sabrina Duranti
- Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma
- Gabriele Andrea Lugli
- Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma
- Leonardo Mancabelli
- Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma
- Federica Armanini
- Centre for Integrative Biology, University of Trento
- Francesca Turroni
- Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma
- Kieran James
- APC Microbiome Institute and School of Microbiology, Bioscience Institute, National University of Ireland
- Pamela Ferretti
- Centre for Integrative Biology, University of Trento
- Valentina Gorfer
- Azienda Provinciale per i Servizi Sanitari
- Chiara Ferrario
- Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma
- Christian Milani
- Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma
- Marta Mangifesta
- GenProbio srl
- Rosaria Anzalone
- Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma
- Moreno Zolfo
- Centre for Integrative Biology, University of Trento
- Alice Viappiani
- GenProbio srl
- Edoardo Pasolli
- Centre for Integrative Biology, University of Trento
- Ilaria Bariletti
- Azienda Provinciale per i Servizi Sanitari
- Rosarita Canto
- Azienda Provinciale per i Servizi Sanitari
- Rosanna Clementi
- Azienda Provinciale per i Servizi Sanitari
- Marina Cologna
- Azienda Provinciale per i Servizi Sanitari
- Tiziana Crifò
- Azienda Provinciale per i Servizi Sanitari
- Giuseppina Cusumano
- Azienda Provinciale per i Servizi Sanitari
- Sabina Fedi
- Azienda Provinciale per i Servizi Sanitari
- Stefania Gottardi
- Azienda Provinciale per i Servizi Sanitari
- Claudia Innamorati
- Azienda Provinciale per i Servizi Sanitari
- Caterina Masè
- Azienda Provinciale per i Servizi Sanitari
- Daniela Postai
- Azienda Provinciale per i Servizi Sanitari
- Daniela Savoi
- Azienda Provinciale per i Servizi Sanitari
- Massimo Soffiati
- Azienda Provinciale per i Servizi Sanitari
- Saverio Tateo
- Azienda Provinciale per i Servizi Sanitari
- Anna Pedrotti
- Azienda Provinciale per i Servizi Sanitari
- Nicola Segata
- Centre for Integrative Biology, University of Trento
- Douwe van Sinderen
- APC Microbiome Institute and School of Microbiology, Bioscience Institute, National University of Ireland
- Marco Ventura
- Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma
- DOI
- https://doi.org/10.1186/s40168-017-0282-6
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 13
Abstract
Abstract Background The correct establishment of the human gut microbiota represents a crucial development that commences at birth. Different hypotheses propose that the infant gut microbiota is derived from, among other sources, the mother’s fecal/vaginal microbiota and human milk. Results The composition of bifidobacterial communities of 25 mother-infant pairs was investigated based on an internal transcribed spacer (ITS) approach, combined with cultivation-mediated and genomic analyses. We identified bifidobacterial strains/communities that are shared between mothers and their corresponding newborns. Notably, genomic analyses together with growth profiling assays revealed that bifidobacterial strains that had been isolated from human milk are genetically adapted to utilize human milk glycans. In addition, we identified particular bacteriophages specific of bifidobacterial species that are common in the viromes of mother and corresponding child. Conclusions This study highlights the transmission of bifidobacterial communities from the mother to her child and implies human milk as a potential vehicle to facilitate this acquisition. Furthermore, these data represent the first example of maternal inheritance of bifidobacterial phages, also known as bifidophages in infants following a vertical transmission route.
Keywords
