Nature Communications (Apr 2022)
Selective optogenetic control of Gq signaling using human Neuropsin
- Ahmed Wagdi,
- Daniela Malan,
- Udhayabhaskar Sathyanarayanan,
- Janosch S. Beauchamp,
- Markus Vogt,
- David Zipf,
- Thomas Beiert,
- Berivan Mansuroglu,
- Vanessa Dusend,
- Mark Meininghaus,
- Linn Schneider,
- Bernd Kalthof,
- J. Simon Wiegert,
- Gabriele M. König,
- Evi Kostenis,
- Robert Patejdl,
- Philipp Sasse,
- Tobias Bruegmann
Affiliations
- Ahmed Wagdi
- Institute for Cardiovascular Physiology, University Medical Center Göttingen
- Daniela Malan
- Institute of Physiology I, Medical Faculty, University of Bonn
- Udhayabhaskar Sathyanarayanan
- Institute for Cardiovascular Physiology, University Medical Center Göttingen
- Janosch S. Beauchamp
- Institute for Cardiovascular Physiology, University Medical Center Göttingen
- Markus Vogt
- Institute for Cardiovascular Physiology, University Medical Center Göttingen
- David Zipf
- Institute for Cardiovascular Physiology, University Medical Center Göttingen
- Thomas Beiert
- Department of Internal Medicine II, University Hospital Bonn, University of Bonn
- Berivan Mansuroglu
- Institute of Physiology I, Medical Faculty, University of Bonn
- Vanessa Dusend
- Institute of Physiology I, Medical Faculty, University of Bonn
- Mark Meininghaus
- Bayer AG, Research & Development, Pharmaceuticals
- Linn Schneider
- Bayer AG, Research & Development, Pharmaceuticals
- Bernd Kalthof
- Bayer AG, Research & Development, Pharmaceuticals
- J. Simon Wiegert
- Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf
- Gabriele M. König
- Molecular, Cellular and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn
- Evi Kostenis
- Molecular, Cellular and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn
- Robert Patejdl
- Oscar-Langendorff Institute of Physiology, Rostock University Medical Center
- Philipp Sasse
- Institute of Physiology I, Medical Faculty, University of Bonn
- Tobias Bruegmann
- Institute for Cardiovascular Physiology, University Medical Center Göttingen
- DOI
- https://doi.org/10.1038/s41467-022-29265-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Gq proteins are one of four major classes of G proteins; optogenetic receptors for selective and repetitive activation of Gq proteins with fast kinetics are lacking. Here the authors report UV light-dependent Gq signalling using human Neuropsin (hOPN5) and demonstrate its potential as an optogenetic tool.
