OncoTargets and Therapy (Sep 2016)

Polymorphisms in the XPC gene and gastric cancer susceptibility in a Southern Chinese population

  • Hua RX,
  • Zhuo ZJ,
  • Shen GP,
  • Zhu J,
  • Zhang SD,
  • Xue WQ,
  • Li XZ,
  • Zhang PF,
  • He J,
  • Jia WH

Journal volume & issue
Vol. Volume 9
pp. 5513 – 5519

Abstract

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Rui-Xi Hua,1,2,* Zhen-Jian Zhuo,3,* Guo-Ping Shen,1 Jinhong Zhu,4 Shao-Dan Zhang,1 Wen-Qiong Xue,1 Xi-Zhao Li,1 Pei-Fen Zhang,1 Jing He,1,5 Wei-Hua Jia1 1Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 2Department of Oncology, The First Affiliated Hospital of Sun Yat-sen University, 3Department of Traditional Chinese Medicine Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangdong, 4Department of Laboratory Medicine and Molecular Epidemiology Laboratory, Harbin Medical University Cancer Hospital, Heilongjiang, 5Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangdong, People’s Republic of China *These authors contributed equally to this work Abstract: Previous studies have reported that XPC gene polymorphisms may modify the individual susceptibility to gastric cancer. In this case–control study with a total of 1,142 cases and 1,173 controls, four potentially functional polymorphisms were genotyped in the XPC gene (rs2228001 A>C, rs2228000 C>T, rs2607775 C>G, and rs1870134 G>C) by Taqman assays and their associations were analyzed with the risk of gastric cancer in a Southern Chinese population. No significant association between any of XPC polymorphisms and gastric cancer risk was detected except for a borderline association with the rs2228000 CT/TT genotype (crude odds ratio =0.86, 95% confidence interval =0.73–1.02, P=0.088) when compared to the rs2228000 CC genotype. Further stratified analysis revealed that the protective effect of rs2228000 CT/TT on the risk of gastric cancer was only significant among subjects older than 58 years. In summary, results indicated that genetic variations in XPC gene may play a weak effect on gastric cancer susceptibility in Southern Chinese population, which warrants further confirmation in larger prospective studies with different ethnic populations. Keywords: gastric cancer, XPC, polymorphism, DNA repair, genetic susceptibility

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