Frontiers in Immunology (Jan 2022)
Fine Mapping Analysis of the MHC Region to Identify Variants Associated With Chinese Vitiligo and SLE and Association Across These Diseases
- Lu Cao,
- Lu Cao,
- Lu Cao,
- Lu Cao,
- Lu Cao,
- Ruixue Zhang,
- Ruixue Zhang,
- Ruixue Zhang,
- Ruixue Zhang,
- Ruixue Zhang,
- Yirui Wang,
- Yirui Wang,
- Yirui Wang,
- Yirui Wang,
- Yirui Wang,
- Xia Hu,
- Xia Hu,
- Xia Hu,
- Xia Hu,
- Xia Hu,
- Liang Yong,
- Liang Yong,
- Liang Yong,
- Liang Yong,
- Liang Yong,
- Bao Li,
- Huiyao Ge,
- Huiyao Ge,
- Huiyao Ge,
- Huiyao Ge,
- Huiyao Ge,
- Weiwei Chen,
- Weiwei Chen,
- Weiwei Chen,
- Weiwei Chen,
- Weiwei Chen,
- Qi Zhen,
- Qi Zhen,
- Qi Zhen,
- Qi Zhen,
- Qi Zhen,
- Yafen Yu,
- Yafen Yu,
- Yafen Yu,
- Yafen Yu,
- Yafen Yu,
- Yiwen Mao,
- Yiwen Mao,
- Yiwen Mao,
- Yiwen Mao,
- Yiwen Mao,
- Zhuo Li,
- Zhuo Li,
- Zhuo Li,
- Zhuo Li,
- Zhuo Li,
- Wencheng Fan,
- Wencheng Fan,
- Wencheng Fan,
- Wencheng Fan,
- Wencheng Fan,
- Liangdan Sun,
- Liangdan Sun,
- Liangdan Sun,
- Liangdan Sun,
- Liangdan Sun
Affiliations
- Lu Cao
- Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
- Lu Cao
- Institute of Dermatology, Anhui Medical University, Hefei, China
- Lu Cao
- Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China
- Lu Cao
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, China
- Lu Cao
- Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, China
- Ruixue Zhang
- Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
- Ruixue Zhang
- Institute of Dermatology, Anhui Medical University, Hefei, China
- Ruixue Zhang
- Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China
- Ruixue Zhang
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, China
- Ruixue Zhang
- Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, China
- Yirui Wang
- Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
- Yirui Wang
- Institute of Dermatology, Anhui Medical University, Hefei, China
- Yirui Wang
- Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China
- Yirui Wang
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, China
- Yirui Wang
- Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, China
- Xia Hu
- Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
- Xia Hu
- Institute of Dermatology, Anhui Medical University, Hefei, China
- Xia Hu
- Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China
- Xia Hu
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, China
- Xia Hu
- Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, China
- Liang Yong
- Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
- Liang Yong
- Institute of Dermatology, Anhui Medical University, Hefei, China
- Liang Yong
- Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China
- Liang Yong
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, China
- Liang Yong
- Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, China
- Bao Li
- The Comprehensive Lab, College of Basic Medicine, Anhui Medical University, Hefei, China
- Huiyao Ge
- Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
- Huiyao Ge
- Institute of Dermatology, Anhui Medical University, Hefei, China
- Huiyao Ge
- Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China
- Huiyao Ge
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, China
- Huiyao Ge
- Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, China
- Weiwei Chen
- Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
- Weiwei Chen
- Institute of Dermatology, Anhui Medical University, Hefei, China
- Weiwei Chen
- Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China
- Weiwei Chen
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, China
- Weiwei Chen
- Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, China
- Qi Zhen
- Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
- Qi Zhen
- Institute of Dermatology, Anhui Medical University, Hefei, China
- Qi Zhen
- Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China
- Qi Zhen
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, China
- Qi Zhen
- Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, China
- Yafen Yu
- Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
- Yafen Yu
- Institute of Dermatology, Anhui Medical University, Hefei, China
- Yafen Yu
- Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China
- Yafen Yu
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, China
- Yafen Yu
- Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, China
- Yiwen Mao
- Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
- Yiwen Mao
- Institute of Dermatology, Anhui Medical University, Hefei, China
- Yiwen Mao
- Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China
- Yiwen Mao
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, China
- Yiwen Mao
- Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, China
- Zhuo Li
- Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
- Zhuo Li
- Institute of Dermatology, Anhui Medical University, Hefei, China
- Zhuo Li
- Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China
- Zhuo Li
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, China
- Zhuo Li
- Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, China
- Wencheng Fan
- Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
- Wencheng Fan
- Institute of Dermatology, Anhui Medical University, Hefei, China
- Wencheng Fan
- Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China
- Wencheng Fan
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, China
- Wencheng Fan
- Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, China
- Liangdan Sun
- Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
- Liangdan Sun
- Institute of Dermatology, Anhui Medical University, Hefei, China
- Liangdan Sun
- Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China
- Liangdan Sun
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, China
- Liangdan Sun
- Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, China
- DOI
- https://doi.org/10.3389/fimmu.2021.758652
- Journal volume & issue
-
Vol. 12
Abstract
The important role of MHC in the pathogenesis of vitiligo and SLE has been confirmed in various populations. To map the most significant MHC variants associated with the risk of vitiligo and SLE, we conducted fine mapping analysis using 1117 vitiligo cases, 1046 SLE cases and 1693 healthy control subjects in the Han-MHC reference panel and 1000 Genomes Project phase 3. rs113465897 (P=1.03×10-13, OR=1.64, 95%CI =1.44–1.87) and rs3129898 (P=4.21×10-17, OR=1.93, 95%CI=1.66–2.25) were identified as being most strongly associated with vitiligo and SLE, respectively. Stepwise conditional analysis revealed additional independent signals at rs3130969(p=1.48×10-7, OR=0.69, 95%CI=0.60–0.79), HLA-DPB1*03:01 (p=1.07×10-6, OR=1.94, 95%CI=1.49–2.53) being linked to vitiligo and HLA-DQB1*0301 (P=4.53×10-7, OR=0.62, 95%CI=0.52-0.75) to SLE. Considering that epidemiological studies have confirmed comorbidities of vitiligo and SLE, we used the GCTA tool to analyse the genetic correlation between these two diseases in the HLA region, the correlation coefficient was 0.79 (P=5.99×10-10, SE=0.07), confirming their similar genetic backgrounds. Our findings highlight the value of the MHC region in vitiligo and SLE and provide a new perspective for comorbidities among autoimmune diseases.
Keywords
