Increased left ventricular end-diastolic pressure after left ventriculography is associated with subsequent congestive heart failure-related hospitalization

Abstract

Context: Left ventricular end-diastolic pressure (LVEDP) reportedly increases after left ventriculography (LVG), and patients with congestive heart failure (CHF) tend to have high LVEDP. We hypothesized that increased LVEDP after LVG is directly associated with hospitalization for CHF. Aims: This study aims to investigate whether a predictive association exists between increased LVEDP after LVG and CHF-related hospitalization. Settings and Design: This was retrospective, single-center (hospital), observational study. Subjects and Methods: We analyzed data of 68 consecutive patients who underwent LVG between March 2015 and July 2017. Patients were divided into the following two groups: those with ΔLVEDP ≥6 mmHg during LVG and those with ΔLVEDP <6 mmHg during LVG. The two groups had similar baseline characteristics, except for body mass index. Statistical Analysis Used: Multivariate Cox proportional hazards analysis was used to determine whether increased LVEDP was associated with CHF-related hospitalization. Results: During the follow-up period (median duration [interquartile range]: 699 [413–994] days), eight patients (11.8%) were hospitalized for CHF. The risk of CHF-related hospitalization was significantly higher in the group with ΔLVEDP ≥6 mmHg than in the group with ΔLVEDP <6 mmHg (hazard ratio, 8.4; 9% confidence interval, 1.3–55.7). A Kaplan–Meier analysis confirmed this finding (P = 0.002). Conclusions: Increased LVEDP after LVG is an independent predictor of CHF-related hospitalization. Determining ΔLVEDP values may facilitate the identification of patients who should undergo early interventions because they are at risk of CHF-related hospitalization.

Keywords

• congestive heart failure
• hospitalization
• left ventricular end-diastolic pressure
• left ventriculography
• risk factors