The Effect of Protoscoleces Treated With Direct Electrical Current on the Cellular Immune Response in Mice Infected With Secondary Hydatid Disease

Abstract

Abstract This study investigates the cellular immune response in BALB/c mice immunized with protoscoleces (PSC) of Echinococcus granulosus of sheep origin, treated with direct electrical current, depending on some immunological criteria including delayed type hypersensitivity (DTH) and mitotic activity of cells obtained from lymphoid organs, spleen and bone marrow. The results revealed an increase in cellular immune response in immunized groups compared with the control group infected for 3 months. An obvious significant increase (P < 0.01) occurred in rate of foot pad thickness 1.83 mm. in immunized group with PSC treated with direct electrical current with potential 5.77mA/cm2 for 2 min. whereas, mice immunized with PSC treated with direct current potential 11.82 mA/cm2 for 2min. too, led to significant increases (P <0.01) in rate of mitotic activity of spleen and bone marrow cells, 61.8%, 70.1% for each, respectively.

Keywords

• protoscoleces treated
• cellular immune
• mice infected