Nature Communications (Aug 2020)
Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders
- Dave T. Gerrard,
- Andrew A. Berry,
- Rachel E. Jennings,
- Matthew J. Birket,
- Peyman Zarrineh,
- Myles G. Garstang,
- Sarah L. Withey,
- Patrick Short,
- Sandra Jiménez-Gancedo,
- Panos N. Firbas,
- Ian Donaldson,
- Andrew D. Sharrocks,
- Karen Piper Hanley,
- Matthew E. Hurles,
- José Luis Gomez-Skarmeta,
- Nicoletta Bobola,
- Neil A. Hanley
Affiliations
- Dave T. Gerrard
- Faculty of Biology, Medicine & Health, Manchester Academic Health Sciences Centre, University of Manchester
- Andrew A. Berry
- Faculty of Biology, Medicine & Health, Manchester Academic Health Sciences Centre, University of Manchester
- Rachel E. Jennings
- Faculty of Biology, Medicine & Health, Manchester Academic Health Sciences Centre, University of Manchester
- Matthew J. Birket
- Faculty of Biology, Medicine & Health, Manchester Academic Health Sciences Centre, University of Manchester
- Peyman Zarrineh
- Faculty of Biology, Medicine & Health, Manchester Academic Health Sciences Centre, University of Manchester
- Myles G. Garstang
- Faculty of Biology, Medicine & Health, Manchester Academic Health Sciences Centre, University of Manchester
- Sarah L. Withey
- Faculty of Biology, Medicine & Health, Manchester Academic Health Sciences Centre, University of Manchester
- Patrick Short
- Wellcome Sanger Institute, Wellcome Genome Campus
- Sandra Jiménez-Gancedo
- Centro Andaluz de Biología del Desarrollo (CABD), Consejo Superior de Investigacionnes Cientificas/Universidad Pablo de Olavide/Junta de Analucía
- Panos N. Firbas
- Centro Andaluz de Biología del Desarrollo (CABD), Consejo Superior de Investigacionnes Cientificas/Universidad Pablo de Olavide/Junta de Analucía
- Ian Donaldson
- Faculty of Biology, Medicine & Health, Manchester Academic Health Sciences Centre, University of Manchester
- Andrew D. Sharrocks
- Faculty of Biology, Medicine & Health, Manchester Academic Health Sciences Centre, University of Manchester
- Karen Piper Hanley
- Faculty of Biology, Medicine & Health, Manchester Academic Health Sciences Centre, University of Manchester
- Matthew E. Hurles
- Wellcome Sanger Institute, Wellcome Genome Campus
- José Luis Gomez-Skarmeta
- Centro Andaluz de Biología del Desarrollo (CABD), Consejo Superior de Investigacionnes Cientificas/Universidad Pablo de Olavide/Junta de Analucía
- Nicoletta Bobola
- Faculty of Biology, Medicine & Health, Manchester Academic Health Sciences Centre, University of Manchester
- Neil A. Hanley
- Faculty of Biology, Medicine & Health, Manchester Academic Health Sciences Centre, University of Manchester
- DOI
- https://doi.org/10.1038/s41467-020-17305-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
How the epigenomic landscape linked to transcription regulates human embryonic development is unclear. Here, the authors analyse the dynamics of H3K27Ac, H3K4me3 and H3K27me3 during the period when organs first assemble as a platform for understanding noncoding developmental disorders.
