Nature Communications (Mar 2021)
N-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic SARS-CoV-2 infection
- Dandan Shan,
- Joseph M. Johnson,
- Syrena C. Fernandes,
- Hannah Suib,
- Soyoon Hwang,
- Danica Wuelfing,
- Muriel Mendes,
- Marcella Holdridge,
- Elaine M. Burke,
- Katie Beauregard,
- Ying Zhang,
- Megan Cleary,
- Samantha Xu,
- Xiao Yao,
- Purvish P. Patel,
- Tatiana Plavina,
- David H. Wilson,
- Lei Chang,
- Kim M. Kaiser,
- Jacob Nattermann,
- Susanne V. Schmidt,
- Eicke Latz,
- Kevin Hrusovsky,
- Dawn Mattoon,
- Andrew J. Ball
Affiliations
- Dandan Shan
- Quanterix Corporation
- Joseph M. Johnson
- Quanterix Corporation
- Syrena C. Fernandes
- Quanterix Corporation
- Hannah Suib
- Quanterix Corporation
- Soyoon Hwang
- Quanterix Corporation
- Danica Wuelfing
- Quanterix Corporation
- Muriel Mendes
- Quanterix Corporation
- Marcella Holdridge
- Quanterix Corporation
- Elaine M. Burke
- Quanterix Corporation
- Katie Beauregard
- Quanterix Corporation
- Ying Zhang
- Quanterix Corporation
- Megan Cleary
- Quanterix Corporation
- Samantha Xu
- Quanterix Corporation
- Xiao Yao
- Quanterix Corporation
- Purvish P. Patel
- Quanterix Corporation
- Tatiana Plavina
- Quanterix Corporation
- David H. Wilson
- Quanterix Corporation
- Lei Chang
- Quanterix Corporation
- Kim M. Kaiser
- Institute of Innate Immunity, University of Bonn
- Jacob Nattermann
- Institute of Innate Immunity, University of Bonn
- Susanne V. Schmidt
- Department of Internal Medicine I, University of Bonn
- Eicke Latz
- Department of Internal Medicine I, University of Bonn
- Kevin Hrusovsky
- Quanterix Corporation
- Dawn Mattoon
- Quanterix Corporation
- Andrew J. Ball
- Quanterix Corporation
- DOI
- https://doi.org/10.1038/s41467-021-22072-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 8
Abstract
Here the authors develop a single molecule array (Simoa) immunoassay for detection of SARS-CoV-2 nucleocapsid protein in venous and dried capillary blood as well as saliva. The assay shows good performance in symptomatic, asymptomatic, and pre-symptomatic PCR+ individuals.
