Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation

Henrick Horita; Christina L. Wysoczynski; Lori A. Walker; Karen S. Moulton; Marcella Li; Allison Ostriker; Rebecca Tucker; Timothy A. McKinsey; Mair E. A. Churchill; Raphael A. Nemenoff; Mary C. M. Weiser-Evans

doi:10.1038/ncomms10830

Nature Communications (Mar 2016)

Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation

Henrick Horita,
Christina L. Wysoczynski,
Lori A. Walker,
Karen S. Moulton,
Marcella Li,
Allison Ostriker,
Rebecca Tucker,
Timothy A. McKinsey,
Mair E. A. Churchill,
Raphael A. Nemenoff,
Mary C. M. Weiser-Evans

Affiliations

Henrick Horita: Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado, Anschutz Medical Campus, 12700 East 19th Avenue, C281, Research Complex 2, Room 7101, Aurora, Colorado 80045, USA
Christina L. Wysoczynski: Department of Pharmacology, University of Colorado, Anschutz Medical Campus
Lori A. Walker: Department of Medicine, Division of Cardiology, University of Colorado, Anschutz Medical Campus
Karen S. Moulton: Department of Medicine, Division of Cardiology, University of Colorado, Anschutz Medical Campus
Marcella Li: Department of Medicine, Division of Cardiology, University of Colorado, Anschutz Medical Campus
Allison Ostriker: Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado, Anschutz Medical Campus, 12700 East 19th Avenue, C281, Research Complex 2, Room 7101, Aurora, Colorado 80045, USA
Rebecca Tucker: Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado, Anschutz Medical Campus, 12700 East 19th Avenue, C281, Research Complex 2, Room 7101, Aurora, Colorado 80045, USA
Timothy A. McKinsey: Department of Medicine, Division of Cardiology, University of Colorado, Anschutz Medical Campus
Mair E. A. Churchill: Department of Pharmacology, University of Colorado, Anschutz Medical Campus
Raphael A. Nemenoff: Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado, Anschutz Medical Campus, 12700 East 19th Avenue, C281, Research Complex 2, Room 7101, Aurora, Colorado 80045, USA
Mary C. M. Weiser-Evans: Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado, Anschutz Medical Campus, 12700 East 19th Avenue, C281, Research Complex 2, Room 7101, Aurora, Colorado 80045, USA

DOI: https://doi.org/10.1038/ncomms10830
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 17

Abstract

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The transcription factor, serum response factor, SRF regulates critical smooth muscle (SM) contractile gene expression but what else controls SM differentiation is unclear. Here, Horita et al. demonstrate that nuclear PTEN acts with SRF at the transcriptional level to maintain the differentiated SM phenotype.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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