Acute promyelocytic leukemia, hypogranular variant: a rare presentation

Abstract

Early diagnosis of acute promyelocytic leukemia (APL) is essential because of its associated life threatening coagulopathy and unique response to all trans-retinoic acid (ATRA) therapy. The characteristic cell morphology supplemented by cytochemistry offers the most rapid means for diagnosis. Here we describe a rare case of acute promyelocytic leukemia-hypogranular variant that poses particular diagnostic challenge.

Keywords

• acute promyelocytic leukemia
• hypogranular variant
• cytochemistry.