Nature Communications (Feb 2023)
MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain
- Dustin C. Becht,
- Brianna J. Klein,
- Akinori Kanai,
- Suk Min Jang,
- Khan L. Cox,
- Bing-Rui Zhou,
- Sabrina K. Phanor,
- Yi Zhang,
- Ruo-Wen Chen,
- Christopher C. Ebmeier,
- Catherine Lachance,
- Maxime Galloy,
- Amelie Fradet-Turcotte,
- Martha L. Bulyk,
- Yawen Bai,
- Michael G. Poirier,
- Jacques Côté,
- Akihiko Yokoyama,
- Tatiana G. Kutateladze
Affiliations
- Dustin C. Becht
- Department of Pharmacology, University of Colorado School of Medicine
- Brianna J. Klein
- Department of Pharmacology, University of Colorado School of Medicine
- Akinori Kanai
- Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, the University of Tokyo
- Suk Min Jang
- Laval University Cancer Research Center, CHU de Québec-UL Research Center-Oncology Division
- Khan L. Cox
- Department of Physics, Ohio State University
- Bing-Rui Zhou
- Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health
- Sabrina K. Phanor
- Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Yi Zhang
- Department of Pharmacology, University of Colorado School of Medicine
- Ruo-Wen Chen
- Department of Physics, Ohio State University
- Christopher C. Ebmeier
- Department of Biochemistry, University of Colorado
- Catherine Lachance
- Laval University Cancer Research Center, CHU de Québec-UL Research Center-Oncology Division
- Maxime Galloy
- Laval University Cancer Research Center, CHU de Québec-UL Research Center-Oncology Division
- Amelie Fradet-Turcotte
- Laval University Cancer Research Center, CHU de Québec-UL Research Center-Oncology Division
- Martha L. Bulyk
- Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Yawen Bai
- Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health
- Michael G. Poirier
- Department of Physics, Ohio State University
- Jacques Côté
- Laval University Cancer Research Center, CHU de Québec-UL Research Center-Oncology Division
- Akihiko Yokoyama
- Tsuruoka Metabolomics Laboratory, National Cancer Center
- Tatiana G. Kutateladze
- Department of Pharmacology, University of Colorado School of Medicine
- DOI
- https://doi.org/10.1038/s41467-023-36368-5
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 20
Abstract
Human acetyltransferases MOZ and MORF mediate development programs and are dysregulated in diseases. Here the authors identified two winged helix (WH) domains in MORF/MOZ and characterized their DNA binding functions, including targeting of CpG by WH1.
