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PECULIARITIES OF FLUOXETINE EFFECTS IN THE REGULATIONOF THE CONDITIONED REFLEX OF PASSIVE AVOIDANCE IN RATSWITH A DIFFERENT PHENOTYPE OF THE NERVOUS SYSTEMAND DIFFERENT LEVELS OF BIOGENIC AMINES

Вестник Московского государственного областного университета: Серия: Естественные науки. 2017;(4):46-55 DOI 10.18384/2310-7189-2017-4-46-55

 

Journal Homepage

Journal Title: Вестник Московского государственного областного университета: Серия: Естественные науки

ISSN: 2072-8352 (Print); 2310-7189 (Online)

Publisher: Moscow Region State University Editorial Office

Society/Institution: Moscow Region State University

LCC Subject Category: Science

Country of publisher: Russian Federation

Language of fulltext: Russian

Full-text formats available: PDF

 

AUTHORS


Исмайлова Хадиджа Юсиф кызы

Гашимова Улдуз Фаизи кызы

Мяджиди Мохаммадрeза

EDITORIAL INFORMATION

Double blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 10 weeks

 

Abstract | Full Text

. The effect of fluoxetine on memory processes is studied by using the model of the conditioned reflex of passive avoidance (CRPA) in male Wistar rats with a different phenotype of the nervous system and a different ratio of the activity of monoaminergic (MA) systems of the brain. High rates of saving of CRPA against the background of administration of a psychopharmacological preparation are found in convulsively-tolerant rats, expressed in an increase in the total time of residence of animals in a safe camera compartment, in an increase in a search activity and a low vegetative index, as well as in an increase in the number of rats with the skill kept. Unlike the control group, convulsive-sensitive rats show a decrease in these parameters. It is assumed that the individual animal's sensitivity to the action of psychopharmacological fluoxetine drug and the direction of effects caused by it in the mnemonic processes are due to the different initial ratio of activity of MA-systems of different brain structures.