Frontiers in Medicine (Jan 2021)
Extracorporeal Membrane Oxygenation for SARS-CoV-2 Acute Respiratory Distress Syndrome: A Retrospective Study From Hubei, China
- Xiaobo Yang,
- Ming Hu,
- Yuan Yu,
- Xijing Zhang,
- Xijing Zhang,
- Minghao Fang,
- Yingtao Lian,
- Yong Peng,
- Lingling Wu,
- Yongran Wu,
- Jun Yi,
- Lu Zhang,
- Bing Wang,
- Zhengqin Xu,
- Boyi Liu,
- Yadong Yang,
- Xiaowei Xiang,
- Xingguang Qu,
- Wenhao Xu,
- Hunian Li,
- Zubo Shen,
- Changming Yang,
- Fengsheng Cao,
- Jie Liu,
- Zhaohui Zhang,
- Lianghai Li,
- Xiaoyun Liu,
- Ruiting Li,
- Xiaojing Zou,
- Huaqing Shu,
- Yaqi Ouyang,
- Dan Xu,
- Jiqian Xu,
- Jiancheng Zhang,
- Hong Liu,
- Hong Qi,
- Xuepeng Fan,
- Chaolin Huang,
- Zhui Yu,
- Shiying Yuan,
- Dingyu Zhang,
- You Shang
Affiliations
- Xiaobo Yang
- Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Ming Hu
- Department of Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, China
- Yuan Yu
- Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Xijing Zhang
- ICU Center of Xijing Hospital, Airforce Medical University, Xi'an, China
- Xijing Zhang
- ICU of Huoshenshan Hospital, Wuhan, China
- Minghao Fang
- Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Yingtao Lian
- Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China
- Yong Peng
- Intensive Care Unit, Xiehe Wuhan Red Cross Hospital, Wuhan, China
- Lingling Wu
- Department of Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, China
- Yongran Wu
- Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Jun Yi
- Department of Cardiothoracic Surgery, The First People's Hospital of Jingmeng, Jingmeng, China
- Lu Zhang
- Department of Critical Care Medicine, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China
- Bing Wang
- 0Department of Critical Care Medicine, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, China
- Zhengqin Xu
- 1Department of Critical Care Medicine, Xiangyang No.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, China
- Boyi Liu
- 2Department of Critical Care Medicine, Taihe Hospitai Affiliated to Hubei University Medicine, Shiyan, China
- Yadong Yang
- 3Department of Critical Care Medicine, Huanggang Central Hospital, Huanggang, China
- Xiaowei Xiang
- 4Department of Critical Care Medicine, Dongfeng Hospital, Affiliated to Hubei University of Medicine, Shiyan, China
- Xingguang Qu
- 5Department of Intensive Care Unit, The First College of Clinical Medical Sciences, China Three Gorges University, Yichang, China
- Wenhao Xu
- 6Department of Critical Care Medicine, Xiaogan Central Hospital, Xiaogan, China
- Hunian Li
- 7Emergency and Critical Care Center, Renmin Hospital, Hubei University of Medicine, Shiyan, China
- Zubo Shen
- 8Department of Critical Care Medicine, Ezhou Central Hospital, Ezhou, China
- Changming Yang
- 9Department of Anesthesiology, The First People's Hospital of Jingmeng, Jingmen, China
- Fengsheng Cao
- Department of Critical Care Medicine, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China
- Jie Liu
- 7Emergency and Critical Care Center, Renmin Hospital, Hubei University of Medicine, Shiyan, China
- Zhaohui Zhang
- 5Department of Intensive Care Unit, The First College of Clinical Medical Sciences, China Three Gorges University, Yichang, China
- Lianghai Li
- 0Department of Critical Care Medicine, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, China
- Xiaoyun Liu
- 1Department of Critical Care Medicine, Xiangyang No.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, China
- Ruiting Li
- Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Xiaojing Zou
- Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Huaqing Shu
- Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Yaqi Ouyang
- Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Dan Xu
- Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Jiqian Xu
- Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Jiancheng Zhang
- Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Hong Liu
- Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Hong Qi
- Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Xuepeng Fan
- 0Department of Critical Care Medicine, Wuhan No.1 Hospital, Wuhan, China
- Chaolin Huang
- 1Research Center for Translational Medicine, Jinyintan Hospital, Wuhan, China
- Zhui Yu
- Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China
- Shiying Yuan
- Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Dingyu Zhang
- 1Research Center for Translational Medicine, Jinyintan Hospital, Wuhan, China
- You Shang
- Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- DOI
- https://doi.org/10.3389/fmed.2020.611460
- Journal volume & issue
-
Vol. 7
Abstract
Background: The data on long-term outcomes of patients infected by SARS-CoV-2 and treated with extracorporeal membrane oxygenation (ECMO) in China are merely available.Methods: A retrospective study included 73 patients infected by SARS-CoV-2 and treated with ECMO in 21 intensive care units in Hubei, China. Data on demographic information, clinical features, laboratory tests, ECMO durations, complications, and living status were collected.Results: The 73 ECMO-treated patients had a median age of 62 (range 33–78) years and 42 (63.6%) were males. Before ECMO initiation, patients had severe respiratory failure on mechanical ventilation with a median PO2/FiO2 of 71.9 [interquartile range (IQR), 58.6–87.0] mmHg and a median PCO2 of 62 [IQR, 43–84] mmHg on arterial blood analyses. The median duration from symptom onset to invasive mechanical ventilation, and to ECMO initiation was19 [IQR, 15–25] days, and 23 [IQR, 19–31] days. Before and after ECMO initiation, the proportions of patients receiving prone position ventilation were 58.9 and 69.9%, respectively. The median duration of ECMO support was 18.5 [IQR 12–30] days. During the treatments with ECMO, major hemorrhages occurred in 31 (42.5%) patients, and oxygenators were replaced in 21 (28.8%) patients. Since ECMO initiation, the 30-day mortality and 60-day mortality were 63.0 and 80.8%, respectively.Conclusions: In Hubei, China, the ECMO-treated patients infected by SARS-CoV-2 were of a broad age range and with severe hypoxemia. The durations of ECMO support, accompanied with increased complications, were relatively long. The long-term mortality in these patients was considerably high.
Keywords
- SARS-CoV-2
- COVID-19
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation
- intensive care unit
- prognosis
