Current treatment strategies targeting histone deacetylase inhibitors in acute lymphocytic leukemia: a systematic review

Yingjun Zhang; Yingjun Zhang; Ge Zhang; Ge Zhang; Yuefang Wang; Yuefang Wang; Lei Ye; Lei Ye; Luyun Peng; Luyun Peng; Rui Shi; Rui Shi; Siqi Guo; Siqi Guo; Jiajing He; Jiajing He; Hao Yang; Hao Yang; Qingkai Dai; Qingkai Dai

doi:10.3389/fonc.2024.1324859

Frontiers in Oncology (Feb 2024)

Current treatment strategies targeting histone deacetylase inhibitors in acute lymphocytic leukemia: a systematic review

Yingjun Zhang,
Yingjun Zhang,
Ge Zhang,
Ge Zhang,
Yuefang Wang,
Yuefang Wang,
Lei Ye,
Lei Ye,
Luyun Peng,
Luyun Peng,
Rui Shi,
Rui Shi,
Siqi Guo,
Siqi Guo,
Jiajing He,
Jiajing He,
Hao Yang,
Hao Yang,
Qingkai Dai,
Qingkai Dai

Affiliations

Yingjun Zhang: Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China
Yingjun Zhang: Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, Sichuan, China
Ge Zhang: Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China
Ge Zhang: Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, Sichuan, China
Yuefang Wang: Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China
Yuefang Wang: Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, Sichuan, China
Lei Ye: Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China
Lei Ye: Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, Sichuan, China
Luyun Peng: Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China
Luyun Peng: Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, Sichuan, China
Rui Shi: Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China
Rui Shi: Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, Sichuan, China
Siqi Guo: Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China
Siqi Guo: Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, Sichuan, China
Jiajing He: Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China
Jiajing He: Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, Sichuan, China
Hao Yang: Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China
Hao Yang: Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, Sichuan, China
Qingkai Dai: Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China
Qingkai Dai: Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, Sichuan, China

DOI: https://doi.org/10.3389/fonc.2024.1324859
Journal volume & issue: Vol. 14

Abstract

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Acute lymphocytic leukemia is a hematological malignancy that primarily affects children. Long-term chemotherapy is effective, but always causes different toxic side effects. With the application of a chemotherapy-free treatment strategy, we intend to demonstrate the most recent results of using one type of epigenetic drug, histone deacetylase inhibitors, in ALL and to provide preclinical evidence for further clinical trials. In this review, we found that panobinostat (LBH589) showed positive outcomes as a monotherapy, whereas vorinostat (SAHA) was a better choice for combinatorial use. Preclinical research has identified chidamide as a potential agent for investigation in more clinical trials in the future. In conclusion, histone deacetylase inhibitors play a significant role in the chemotherapy-free landscape in cancer treatment, particularly in acute lymphocytic leukemia.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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