An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex

Keiko Kawauchi; Wataru Sugimoto; Takatoshi Yasui; Kohei Murata; Katsuhiko Itoh; Kazuki Takagi; Takaaki Tsuruoka; Kensuke Akamatsu; Hisae Tateishi-Karimata; Naoki Sugimoto; Daisuke Miyoshi

doi:10.1038/s41467-018-04771-y

Nature Communications (Jun 2018)

An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex

Keiko Kawauchi,
Wataru Sugimoto,
Takatoshi Yasui,
Kohei Murata,
Katsuhiko Itoh,
Kazuki Takagi,
Takaaki Tsuruoka,
Kensuke Akamatsu,
Hisae Tateishi-Karimata,
Naoki Sugimoto,
Daisuke Miyoshi

Affiliations

Keiko Kawauchi: Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University
Wataru Sugimoto: Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University
Takatoshi Yasui: Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University
Kohei Murata: Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University
Katsuhiko Itoh: Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University
Kazuki Takagi: Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University
Takaaki Tsuruoka: Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University
Kensuke Akamatsu: Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University
Hisae Tateishi-Karimata: Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University
Naoki Sugimoto: Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University
Daisuke Miyoshi: Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University

DOI: https://doi.org/10.1038/s41467-018-04771-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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Hyperactivity of the gene NRAS contributes to the proliferation and metastatic nature of many types of cancer cells. Here, the authors show that NRAS can be controlled by an anionic phthalocyanine coordinating Zn2+ in combination with photo-irradiation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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