History, Experience, Opportunities, and Challenges in Esophageal Cancer Prevention and Treatment in Linxian, Henan Province, A High Incidence Area for Esophageal Cancer

Lidong WANG; Xiaoqian ZHANG; Xin SONG; Xueke ZHAO; Duo YOU; Lingling LEI; Ruihua XU; Jin HUANG; Wenli HAN; Ran WANG; Qide BAO; Aifang JI; Lei MA; Shegan GAO

doi:10.3971/j.issn.1000-8578.2025.24.1329

Zhongliu Fangzhi Yanjiu (Apr 2025)

History, Experience, Opportunities, and Challenges in Esophageal Cancer Prevention and Treatment in Linxian, Henan Province, A High Incidence Area for Esophageal Cancer

Lidong WANG,
Xiaoqian ZHANG,
Xin SONG,
Xueke ZHAO,
Duo YOU,
Lingling LEI,
Ruihua XU,
Jin HUANG,
Wenli HAN,
Ran WANG,
Qide BAO,
Aifang JI,
Lei MA,
Shegan GAO

Affiliations

Lidong WANG: Henan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolism Disorder and Esophageal Cancer Prevention & Treatment of the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
Xiaoqian ZHANG: Henan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolism Disorder and Esophageal Cancer Prevention & Treatment of the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
Xin SONG: Henan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolism Disorder and Esophageal Cancer Prevention & Treatment of the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
Xueke ZHAO: Henan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolism Disorder and Esophageal Cancer Prevention & Treatment of the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
Duo YOU: Henan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolism Disorder and Esophageal Cancer Prevention & Treatment of the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
Lingling LEI: Henan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolism Disorder and Esophageal Cancer Prevention & Treatment of the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
Ruihua XU: Henan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolism Disorder and Esophageal Cancer Prevention & Treatment of the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
Jin HUANG: Henan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolism Disorder and Esophageal Cancer Prevention & Treatment of the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
Wenli HAN: Henan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolism Disorder and Esophageal Cancer Prevention & Treatment of the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
Ran WANG: Henan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolism Disorder and Esophageal Cancer Prevention & Treatment of the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
Qide BAO: Department of Oncology, Anyang District Hospital, Anyang 455000, China
Aifang JI: Department of Clinical Laboratory, Heping Hospital Affiliated to Changzhi Medical College, Changzhi 046000, China
Lei MA: Henan Provincial Key Laboratory of Tumor Molecular Biology Medicine, Nanyang First People's Hospital, Nanyang 473000, China
Shegan GAO: Department of Oncology, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, China

DOI: https://doi.org/10.3971/j.issn.1000-8578.2025.24.1329
Journal volume & issue: Vol. 52, no. 4
pp. 251 – 255

Abstract

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Linxian County in Henan Province, Northern China is known as the region with the highest incidence and mortality rate of esophageal cancer worldwide. Since 1959, the Henan medical team has conducted field work on esophageal cancer prevention and treatment in Linxian. Through three generations of effort exerted by oncologists over 65 years of research on esophageal cancer prevention and treatment in Linxian, the incidence rate of esophageal squamous cell carcinoma in this area has dropped by nearly 50%, and the 5-year survival rate has increased to 40%, reaching the international leading level. This article aims to summarize the history, present opportunities and new challenges, and explore the experience of esophageal cancer prevention and treatment in Linxian (referred to as the “Linxian experience”), providing reference and guidance to cancer prevention and treatment research in China.

Published in Zhongliu Fangzhi Yanjiu

ISSN: 1000-8578 (Print)
Publisher: Magazine House of Cancer Research on Prevention and Treatment
Country of publisher: China
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://www.zlfzyj.com

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