Analysis of a free boundary problem for vascularized tumor growth with time delays and almost periodic nutrient supply

Abstract

In this research, we have proposed and investigated a time-delayed free boundary problem concerning tumor growth in the presence of almost periodic nutrient supply with angiogenesis. This study primarily focused on examining the impact of almost periodic nutrient supply, angiogenesis, and time delay on tumor growth dynamics. We analyzed the existence, uniqueness, and exponential stability of almost periodic solutions. Furthermore, we established conditions for the disappearance of almost periodic oscillations in tumors. The existence and uniqueness of almost periodic solutions were proven, while sufficient conditions for the exponential stability of the unique solution were established. Finally, computer simulations were employed to illustrate our results.

Keywords

• tumor growth
• angiogenesis
• almost periodic solution
• existence and uniqueness
• stability