ANGIOTENSIN II TYPE-1 RECEPTOR (AT1R) DISTRIBUTION IN BPH, HIGH GRADE  PIN AND  ADENOCARCINOMA OF THE PROSTATE

Isdianto Septiadi; Suwandi Sugandi; Bambang S Noegroho; Tjahjodjati Tjahjodjati; Ferry Safriadi; Safendra Siregar; Ricky Adriansjah; Kuncoro Adi; Aaron T Sihombing; Sawkar V Pramod; Ramlan Nasution; Betthy S Hernowo

doi:10.32421/juri.v17i2.348

Jurnal Urologi Indonesia (Nov 2016)

ANGIOTENSIN II TYPE-1 RECEPTOR (AT1R) DISTRIBUTION IN BPH, HIGH GRADE PIN AND ADENOCARCINOMA OF THE PROSTATE

Isdianto Septiadi,
Suwandi Sugandi,
Bambang S Noegroho,
Tjahjodjati Tjahjodjati,
Ferry Safriadi,
Safendra Siregar,
Ricky Adriansjah,
Kuncoro Adi,
Aaron T Sihombing,
Sawkar V Pramod,
Ramlan Nasution,
Betthy S Hernowo

Affiliations

Isdianto Septiadi: Department of Urology, Faculty of Medicine/Padjadjaran University, Hasan Sadikin Hospital, Bandung.
Suwandi Sugandi: Department of Urology, Faculty of Medicine/Padjadjaran University, Hasan Sadikin Hospital, Bandung.
Bambang S Noegroho: Department of Urology, Faculty of Medicine/Padjadjaran University, Hasan Sadikin Hospital, Bandung.
Tjahjodjati Tjahjodjati: Department of Urology, Faculty of Medicine/Padjadjaran University, Hasan Sadikin Hospital, Bandung.
Ferry Safriadi: Department of Urology, Faculty of Medicine/Padjadjaran University, Hasan Sadikin Hospital, Bandung.
Safendra Siregar: Department of Urology, Faculty of Medicine/Padjadjaran University, Hasan Sadikin Hospital, Bandung.
Ricky Adriansjah: Department of Urology, Faculty of Medicine/Padjadjaran University, Hasan Sadikin Hospital, Bandung.
Kuncoro Adi: Department of Urology, Faculty of Medicine/Padjadjaran University, Hasan Sadikin Hospital, Bandung.
Aaron T Sihombing: Department of Urology, Faculty of Medicine/Padjadjaran University, Hasan Sadikin Hospital, Bandung.
Sawkar V Pramod: Department of Urology, Faculty of Medicine/Padjadjaran University, Hasan Sadikin Hospital, Bandung.
Ramlan Nasution: Department of Urology, Faculty of Medicine/Padjadjaran University, Hasan Sadikin Hospital, Bandung.
Betthy S Hernowo: Department of Anatomical Pathology, Faculty of Medicine/Padjadjaran University, Hasan Sadikin Hospital, Bandung.

DOI: https://doi.org/10.32421/juri.v17i2.348
Journal volume & issue: Vol. 17, no. 2

Abstract

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Objective: The aim of the study was to detect the differences in number and the distribution of angiotensin II type-1 receptor (AT1R) in BPH, high grade PIN, and adenocarcinoma of the prostate. Material & method: A prospective study was performed in RSHS, in collaboration with the Department of Anatomical Pathology. Prostate samples were taken by TUR of the prostate, and then divided into 5 groups. They were BPH, high grade PIN, adenocarcinoma of the prostate in 3 difference grades (well, moderate, and poorly differentiated). Kidney tissue for control. Immunohistochemical staining was done to determine the angiotensin II type-1 (AT1R) receptor distribution as primary antibody used was mouse monoclonal antibody AT1 (TONI-1): sc-57036, Santa Cruz Biotechnology Inc., CA. Results: Angiotensin II type-1 receptor was found in material of BPH, high grade PIN and adenocarcinoma of the prostate. The number and distribution of the receptors were not different. Conclusion: There are no significant differences in number and distribution of angiotensin II type-1 receptor on BPH, high grade PIN, and adenocarcinoma of the prostate.

Published in Jurnal Urologi Indonesia

ISSN: 0853-442X (Print); 2355-1402 (Online)
Publisher: IKATAN AHLI UROLOGI INDONESIA
Country of publisher: Indonesia
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the genitourinary system. Urology
Website: http://juri.urologi.or.id/juri/index

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