Nature Communications (May 2021)
Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells
- Xuan Sun,
- Benjamin Cao,
- Marina Naval-Sanchez,
- Tony Pham,
- Yu Bo Yang Sun,
- Brenda Williams,
- Shen Y. Heazlewood,
- Nikita Deshpande,
- Jinhua Li,
- Felix Kraus,
- James Rae,
- Quan Nguyen,
- Hamed Yari,
- Jan Schröder,
- Chad K. Heazlewood,
- Madeline Fulton,
- Jessica Hatwell-Humble,
- Kaustav Das Gupta,
- Ronan Kapetanovic,
- Xiaoli Chen,
- Matthew J. Sweet,
- Robert G. Parton,
- Michael T. Ryan,
- Jose M. Polo,
- Christian M. Nefzger,
- Susan K. Nilsson
Affiliations
- Xuan Sun
- Biomedical Manufacturing Commonwealth Scientific and Industrial Research Organisation (CSIRO)
- Benjamin Cao
- Biomedical Manufacturing Commonwealth Scientific and Industrial Research Organisation (CSIRO)
- Marina Naval-Sanchez
- Institute for Molecular Bioscience, The University of Queensland
- Tony Pham
- Institute for Molecular Bioscience, The University of Queensland
- Yu Bo Yang Sun
- Australian Regenerative Medicine Institute, Monash University
- Brenda Williams
- Biomedical Manufacturing Commonwealth Scientific and Industrial Research Organisation (CSIRO)
- Shen Y. Heazlewood
- Biomedical Manufacturing Commonwealth Scientific and Industrial Research Organisation (CSIRO)
- Nikita Deshpande
- Institute for Molecular Bioscience, The University of Queensland
- Jinhua Li
- Monash Biomedicine Discovery Institute
- Felix Kraus
- Monash Biomedicine Discovery Institute
- James Rae
- Institute for Molecular Bioscience, The University of Queensland
- Quan Nguyen
- Institute for Molecular Bioscience, The University of Queensland
- Hamed Yari
- Institute for Molecular Bioscience, The University of Queensland
- Jan Schröder
- Australian Regenerative Medicine Institute, Monash University
- Chad K. Heazlewood
- Biomedical Manufacturing Commonwealth Scientific and Industrial Research Organisation (CSIRO)
- Madeline Fulton
- Biomedical Manufacturing Commonwealth Scientific and Industrial Research Organisation (CSIRO)
- Jessica Hatwell-Humble
- Biomedical Manufacturing Commonwealth Scientific and Industrial Research Organisation (CSIRO)
- Kaustav Das Gupta
- Institute for Molecular Bioscience, The University of Queensland
- Ronan Kapetanovic
- Institute for Molecular Bioscience, The University of Queensland
- Xiaoli Chen
- Institute for Molecular Bioscience, The University of Queensland
- Matthew J. Sweet
- Institute for Molecular Bioscience, The University of Queensland
- Robert G. Parton
- Institute for Molecular Bioscience, The University of Queensland
- Michael T. Ryan
- Monash Biomedicine Discovery Institute
- Jose M. Polo
- Australian Regenerative Medicine Institute, Monash University
- Christian M. Nefzger
- Australian Regenerative Medicine Institute, Monash University
- Susan K. Nilsson
- Biomedical Manufacturing Commonwealth Scientific and Industrial Research Organisation (CSIRO)
- DOI
- https://doi.org/10.1038/s41467-021-22863-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Aged hematopoietic stem cells (HSC) are characterised by reduced regenerative potential and a loss of quiescence. Here, the authors show nicotinamide riboside treatment shrinks the age-enlarged stem cell pool and shifts aged HSC functionally, metabolically and molecularly towards the young state.
