Nature Communications (Nov 2021)

Introns control stochastic allele expression bias

  • Bryan Sands,
  • Soo Yun,
  • Alexander R. Mendenhall

DOI
https://doi.org/10.1038/s41467-021-26798-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Stochastic autosomal allele expression bias has been widely documented, yet the mechanisms behind this consequential phenomenon remain poorly understood. Here the authors show that the presence of introns greatly restricts monoallelic expression in a C. elegans model.