Communications Medicine (Jul 2022)

Hybrid-control arm construction using historical trial data for an early-phase, randomized controlled trial in metastatic colorectal cancer

  • Chen Li,
  • Ana Ferro,
  • Shivani K. Mhatre,
  • Danny Lu,
  • Marcus Lawrance,
  • Xiao Li,
  • Shi Li,
  • Simon Allen,
  • Jayesh Desai,
  • Marwan Fakih,
  • Michael Cecchini,
  • Katrina S. Pedersen,
  • Tae You Kim,
  • Irmarie Reyes-Rivera,
  • Neil H. Segal,
  • Christelle Lenain

DOI
https://doi.org/10.1038/s43856-022-00155-y
Journal volume & issue
Vol. 2, no. 1
pp. 1 – 8

Abstract

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Li et al. report outcomes from the atezolizumab/isatuximab arm of the phase Ib/II MORPHEUS-CRC trial in patients with metastatic colorectal cancer. In addition, the authors leverage historical control data from the phase III IMblaze370 study to provide more precise treatment effect estimates.