Journal of Medical Biochemistry (Jan 2024)

The relationship between lactate dehydrogenase and Apolipoprotein A1 levels in patients with severe pneumonia

  • Wang Jiang,
  • Wang Ronghua,
  • Zhou Ying,
  • Ma Yao,
  • Xiong Chunyan

DOI
https://doi.org/10.5937/jomb0-45782
Journal volume & issue
Vol. 43, no. 2
pp. 290 – 298

Abstract

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Background: To investigate the relationship between lactate dehydrogenase and apolipoprotein A1 levels and the condition and prognosis of patients with severe pneumonia. Methods: Data was collected from 204 patients with severe pneumonia who were hospitalized from January 1, 2019 to December 1, 2021 in Zhaotong First People's Hospital (respiratory intensive care unit (RICU)), and divided into survival group (160 patients) and death group (44 patients) according to their hospitalization outcome. The relationship between lactate dehydrogenase and apolipoprotein A1 levels and general information, disease, and treatment needs of patients with severe pneumonia was analyzed, and lactate dehydrogenase, apolipoprotein A1, neutrophil-to-lymphocyte ratio, hematocrit, C-reactive protein, calcitoninogen, D-dimer, Acute Physiology and Chronic Health Status Rating System II, and Pneumonia Severity Index scores were compared between the survival and death groups. The value of these indicators in determining the prognosis of patients was analyzed using subject operating characteristic (ROC) curves. Logistic regression was used to analyze the risk factors for death from severe pneumonia. Results: The age and pneumonia type differed significantly between the two groups (P0.05). LDH (Lactate Dehydrogenase) and ApoA1 (Apolipoprotein A1) levels showed significant differences among different age groups with severe pneumonia (P0.05). LDH and ApoA1 levels were higher in severe pneumonia patients with acute exacerbation or MODS (multiple organ dysfunction syndrome), compared to those without (P0.05). LDH and ApoA1, when combined, had a higher predictive value for severe pneumonia mortality (Area Under the Curve, AUC=0.873, P289 U/mL and ApoA1<0.92 mg/mL increased the risk of severe pneumonia mortality (OR=4.275, 0.548, P<0.05). Conclusion: Elevated LDH levels and reduced ApoA1 levels in patients with severe pneumonia are valuable in assessing patients' conditions and prognosis, and can provide assistance in the early assessment of patients' conditions and diagnosis and treatment.

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