Nature Communications (Apr 2020)
Methylation of Salmonella Typhimurium flagella promotes bacterial adhesion and host cell invasion
- Julia A. Horstmann,
- Michele Lunelli,
- Hélène Cazzola,
- Johannes Heidemann,
- Caroline Kühne,
- Pascal Steffen,
- Sandra Szefs,
- Claire Rossi,
- Ravi K. Lokareddy,
- Chu Wang,
- Laurine Lemaire,
- Kelly T. Hughes,
- Charlotte Uetrecht,
- Hartmut Schlüter,
- Guntram A. Grassl,
- Theresia E. B. Stradal,
- Yannick Rossez,
- Michael Kolbe,
- Marc Erhardt
Affiliations
- Julia A. Horstmann
- Junior Research Group Infection Biology of Salmonella, Helmholtz Centre for Infection Research
- Michele Lunelli
- Department for Structural Infection Biology, Center for Structural Systems Biology (CSSB) & Helmholtz Centre for Infection Research
- Hélène Cazzola
- Université de Technologie de Compiègne, Alliance Sorbonne Université, UMR7025 CNRS Enzyme and Cell Engineering Laboratory
- Johannes Heidemann
- Heinrich Pette Institute, Leibniz Institute for Experimental Virology
- Caroline Kühne
- Humboldt-Universität zu Berlin, Institute for Biology – Bacterial Physiology
- Pascal Steffen
- Institute of Clinical Chemistry and Laboratory Medicine, Mass Spectrometric Proteomics Group, University Medical Center Hamburg-Eppendorf
- Sandra Szefs
- Junior Research Group Infection Biology of Salmonella, Helmholtz Centre for Infection Research
- Claire Rossi
- Université de Technologie de Compiègne, Alliance Sorbonne Université, UMR7025 CNRS Enzyme and Cell Engineering Laboratory
- Ravi K. Lokareddy
- Department of Biochemistry and Molecular Biology, Thomas Jefferson University
- Chu Wang
- Department for Structural Infection Biology, Center for Structural Systems Biology (CSSB) & Helmholtz Centre for Infection Research
- Laurine Lemaire
- Université de Technologie de Compiègne, Alliance Sorbonne Université, UMR7025 CNRS Enzyme and Cell Engineering Laboratory
- Kelly T. Hughes
- University of Utah, Department of Biology
- Charlotte Uetrecht
- Heinrich Pette Institute, Leibniz Institute for Experimental Virology
- Hartmut Schlüter
- Institute of Clinical Chemistry and Laboratory Medicine, Mass Spectrometric Proteomics Group, University Medical Center Hamburg-Eppendorf
- Guntram A. Grassl
- Institute of Medical Microbiology and Hospital Epidemiology, Medizinische Hochschule Hannover, and German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig
- Theresia E. B. Stradal
- Department of Cell Biology, Helmholtz Centre for Infection Research
- Yannick Rossez
- Université de Technologie de Compiègne, Alliance Sorbonne Université, UMR7025 CNRS Enzyme and Cell Engineering Laboratory
- Michael Kolbe
- Department for Structural Infection Biology, Center for Structural Systems Biology (CSSB) & Helmholtz Centre for Infection Research
- Marc Erhardt
- Junior Research Group Infection Biology of Salmonella, Helmholtz Centre for Infection Research
- DOI
- https://doi.org/10.1038/s41467-020-15738-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
Flagellin proteins of Salmonella flagella are methylated. Here, the authors show that flagellin methylation facilitates adhesion of Salmonella to hydrophobic host-cell surfaces, and contributes to efficient gut colonization and host infection.
