Jag1-Notch cis-interaction determines cell fate segregation in pancreatic development

Xiaochan Xu; Philip Allan Seymour; Kim Sneppen; Ala Trusina; Anuska la Rosa Egeskov-Madsen; Mette Christine Jørgensen; Mogens Høgh Jensen; Palle Serup

doi:10.1038/s41467-023-35963-w

Nature Communications (Jan 2023)

Jag1-Notch cis-interaction determines cell fate segregation in pancreatic development

Xiaochan Xu,
Philip Allan Seymour,
Kim Sneppen,
Ala Trusina,
Anuska la Rosa Egeskov-Madsen,
Mette Christine Jørgensen,
Mogens Høgh Jensen,
Palle Serup

Affiliations

Xiaochan Xu: The Niels Bohr Institute, University of Copenhagen
Philip Allan Seymour: Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen
Kim Sneppen: The Niels Bohr Institute, University of Copenhagen
Ala Trusina: The Niels Bohr Institute, University of Copenhagen
Anuska la Rosa Egeskov-Madsen: Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen
Mette Christine Jørgensen: Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen
Mogens Høgh Jensen: The Niels Bohr Institute, University of Copenhagen
Palle Serup: Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen

DOI: https://doi.org/10.1038/s41467-023-35963-w
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 17

Abstract

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Notch signaling is crucial for pancreatic cell fate choice. With mathematical modeling and experiments, Xu et al. provides new insights into how different Notch ligands and Hes1 oscillation guide the spatial-temporal dynamics of cell differentiation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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