SINTESIS 4–HIDROKSI–3–KLOROBENZALDEHID DARI p–HIDROKSIBENZALDEHID DAN GAS Cl2

Abstract

Curcumin is a compound which potential to be developed. The curcumin analogues have been synthesized. The compound 3–chloro–4–hydroxybenzaldehyde was used as starting material in the synthesis of curcumin analogues with Cl substituent on the aromatic ring. The compound of 3–chloro–4–hydroxybenzaldehyde were synthesized by chlorination reaction between p–hydroxybenzaldehyde and Cl2 gas. The purity of 3–chloro–4–hydroxybenzaldehyde was determined base on the melting range, thin layer chromatography and LC–MS. The structure identification of the compound was observed done by spectrometry techniques, including mass spectra (ESI–MS), infrared spectra (cm-1, KBr), Nuclear Magnetic resonance proton spectra (δ, ppm, DMSO-d6, 1H–NMR, 500 MHz) and UV–Vis spectra. Chlorination reaction of p–hydroxybenzaldehyde produced yellow crystal of 3–chloro–4–hydroxybenzaldehyde, its melting range is 128.1 to 130.8ºC. The average yield obtained of this reseach is 51.37%.

Keywords

• 3–chloro–4–hydroxybenzaldehyde
• chlorination
• halogenation