Nature Communications (Oct 2021)
A metabolome atlas of the aging mouse brain
- Jun Ding,
- Jian Ji,
- Zachary Rabow,
- Tong Shen,
- Jacob Folz,
- Christopher R. Brydges,
- Sili Fan,
- Xinchen Lu,
- Sajjan Mehta,
- Megan R. Showalter,
- Ying Zhang,
- Renee Araiza,
- Lynette R. Bower,
- K. C. Kent Lloyd,
- Oliver Fiehn
Affiliations
- Jun Ding
- West Coast Metabolomics Center, UC Davis Genome Center, University of California, Davis
- Jian Ji
- School of Food Science, State Key Laboratory of Food Science and Technology, National Engineering Research Center for Functional Foods, Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University
- Zachary Rabow
- West Coast Metabolomics Center, UC Davis Genome Center, University of California, Davis
- Tong Shen
- West Coast Metabolomics Center, UC Davis Genome Center, University of California, Davis
- Jacob Folz
- West Coast Metabolomics Center, UC Davis Genome Center, University of California, Davis
- Christopher R. Brydges
- West Coast Metabolomics Center, UC Davis Genome Center, University of California, Davis
- Sili Fan
- West Coast Metabolomics Center, UC Davis Genome Center, University of California, Davis
- Xinchen Lu
- West Coast Metabolomics Center, UC Davis Genome Center, University of California, Davis
- Sajjan Mehta
- West Coast Metabolomics Center, UC Davis Genome Center, University of California, Davis
- Megan R. Showalter
- West Coast Metabolomics Center, UC Davis Genome Center, University of California, Davis
- Ying Zhang
- West Coast Metabolomics Center, UC Davis Genome Center, University of California, Davis
- Renee Araiza
- Mouse Biology Program, and Department of Surgery, School of Medicine, University of California, Davis
- Lynette R. Bower
- Mouse Biology Program, and Department of Surgery, School of Medicine, University of California, Davis
- K. C. Kent Lloyd
- Mouse Biology Program, and Department of Surgery, School of Medicine, University of California, Davis
- Oliver Fiehn
- West Coast Metabolomics Center, UC Davis Genome Center, University of California, Davis
- DOI
- https://doi.org/10.1038/s41467-021-26310-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Metabolites play an important role in physiology, yet the complexity of the metabolome and its interaction with disease and aging is poorly understood. Here the authors present a comprehensive atlas of the mouse brain metabolome and how it changes during aging.
