Case Reports in Neurology (Feb 2011)

Cerebellar Degeneration as Presenting Symptom of Recurrent Endometrial Stromal Sarcoma with Sex-Cord Elements

  • Michael Gliem,
  • Dimitris Panayotopoulos,
  • Peter Feindt,
  • Sebastian Heikaus,
  • Markus C. Fleisch,
  • Rüdiger J. Seitz

DOI
https://doi.org/10.1159/000324927
Journal volume & issue
Vol. 3, no. 1
pp. 54 – 61

Abstract

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We report a 66-year-old woman with slowly progressive ataxia due to cerebellar atrophy. Imaging studies revealed multiple lesions in both the lungs and dorsal subpleural space. A biopsy identified the lesions as metastases of a low-grade endometrial stromal sarcoma containing sex-cord elements. The histological appearance was identical to a uterine tumor the patient was treated for with hysterectomy 16 years before. The metastases were removed surgically, and after 3 months ataxia had regressed. We conclude that the presenting cerebellar degeneration in this patient resulted from the metastatic recurrence of the endometrial tumor.

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