Nature Communications (Oct 2020)
Th17-inducing autologous dendritic cell vaccination promotes antigen-specific cellular and humoral immunity in ovarian cancer patients
- Matthew S. Block,
- Allan B. Dietz,
- Michael P. Gustafson,
- Kimberly R. Kalli,
- Courtney L. Erskine,
- Bahaaeldin Youssef,
- Geraldine V. Vijay,
- Jacob B. Allred,
- Kevin D. Pavelko,
- Michael A. Strausbauch,
- Yi Lin,
- Megan E. Grudem,
- Aminah Jatoi,
- Carolyn M. Klampe,
- Andrea E. Wahner-Hendrickson,
- S. John Weroha,
- Gretchen E. Glaser,
- Amanika Kumar,
- Carrie L. Langstraat,
- Mary L. Solseth,
- Michael C. Deeds,
- Keith L. Knutson,
- Martin J. Cannon
Affiliations
- Matthew S. Block
- Department of Oncology, Mayo Clinic
- Allan B. Dietz
- Department of Laboratory Medicine and Pathology, Mayo Clinic
- Michael P. Gustafson
- Department of Laboratory Medicine and Pathology, Mayo Clinic
- Kimberly R. Kalli
- Department of Oncology, Mayo Clinic
- Courtney L. Erskine
- Department of Immunology, Mayo Clinic
- Bahaaeldin Youssef
- Department of Immunology, Mayo Clinic
- Geraldine V. Vijay
- Department of Immunology, Mayo Clinic
- Jacob B. Allred
- Mayo Clinic Cancer Statistics, Mayo Clinic
- Kevin D. Pavelko
- Immune Monitoring Core, Mayo Clinic
- Michael A. Strausbauch
- Immune Monitoring Core, Mayo Clinic
- Yi Lin
- Department of Medicine, Mayo Clinic
- Megan E. Grudem
- Department of Oncology, Mayo Clinic
- Aminah Jatoi
- Department of Oncology, Mayo Clinic
- Carolyn M. Klampe
- Department of Oncology, Mayo Clinic
- Andrea E. Wahner-Hendrickson
- Department of Oncology, Mayo Clinic
- S. John Weroha
- Department of Oncology, Mayo Clinic
- Gretchen E. Glaser
- Department of Obstetrics and Gynecology
- Amanika Kumar
- Department of Obstetrics and Gynecology
- Carrie L. Langstraat
- Department of Obstetrics and Gynecology
- Mary L. Solseth
- Department of Laboratory Medicine and Pathology, Mayo Clinic
- Michael C. Deeds
- Department of Laboratory Medicine and Pathology, Mayo Clinic
- Keith L. Knutson
- Department of Immunology, Mayo Clinic
- Martin J. Cannon
- Department of Microbiology and Immunology, University of Arkansas for Medical Sciences
- DOI
- https://doi.org/10.1038/s41467-020-18962-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
The folate receptor alpha (FRα) is overexpressed in the majority of high-grade serous ovarian cancers and has been proposed as a candidate vaccine antigen. Here the authors report the safety and immunogenicity of Th17-inducing dendritic cells pulsed with FRα-derived epitopes in an early phase I clinical trial with ovarian cancer patients.
