Prescription of pharmacotherapy and blood pressure control among hypertensive outpatients in two semi-urban hospitals in Cameroon: a cross-sectional study

Abstract

INTRODUCTION: Several international guidelines are available on drug treatment for hypertension, but the control of hypertension remains very poor in sub-Saharan Africa (SSA). We investigated the commonly prescribed antihypertensive drugs and their association with blood pressure (BP) control in adult Cameroonians. METHODS: we consecutively recruited hypertensive outpatients attending the Buea and Limbe Regional Hospitals (Southwest Region of Cameroon). Controlled BP was defined as BP 140/90mmHg in hypertensive patients aged 60 years or younger, diabetics or patients with chronic kidney disease or a BP 150/90mmHg in non-diabetic hypertensive patients older than 60 years of age (JNC8). RESULTS: of the 408 participants included (mean age 61.1 years), 67% were female. The median duration of hypertension was 6 years and the median duration of the current treatment was 22 weeks. Commonly prescribed antihypertensives were calcium channel blockers (CCB, 35.1%), thiazide/thiazide-like diuretics (TD/TLD, 26.1%) and angiotensin-converting enzyme inhibitors (ACEI,19.5%). The median monthly cost of antihypertensive was 10279.6 CFA (approximately equal to US$ 172). 70% of participants were receiving at least 2 drugs, with ACEI+TD/TLD, CCB+TD/TLD, and ACEI+CCB+TD/TLD being the most frequent. The rate of BP control was 52% overall, and 60% in participants on monotherapy. CONCLUSION: CCBs were the most prescribed single antihypertensive drugs in this setting while ACEI+TD/TLD was the most common combination. About half of patients were at target BP control levels Improving availability and affordability of these medications may improve hypertension management and control.

Keywords

• hypertension
• antihypertensive drugs
• blood pressure
• cameroon