Targeting non-coding RNA family members with artificial endonuclease XNAzymes

Maria J. Donde; Adam M. Rochussen; Saksham Kapoor; Alexander I. Taylor

doi:10.1038/s42003-022-03987-5

Communications Biology (Sep 2022)

Targeting non-coding RNA family members with artificial endonuclease XNAzymes

Maria J. Donde,
Adam M. Rochussen,
Saksham Kapoor,
Alexander I. Taylor

Affiliations

Maria J. Donde: Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, University of Cambridge
Adam M. Rochussen: Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, University of Cambridge
Saksham Kapoor: Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, University of Cambridge
Alexander I. Taylor: Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, University of Cambridge

DOI: https://doi.org/10.1038/s42003-022-03987-5
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 10

Abstract

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Engineered RNA endonuclease XNAzymes can specifically target individual disease-associated non-coding RNAs (ncRNAs) in vitro with potential as platform technology for precision detection or knockdown of individual microRNAs or longer ncRNAs.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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