Hemoglobin A1c and Angiographic Severity with Coronary Artery Disease: A Cross-Sectional Study

Abstract

Yugang Yan,1,2 Ronghua Gao,3 Shaohui Zhang,3 Zhencai Gao,3 Anyong Chen,3 Jianjun Wang,3 Shufang Zhang,3 Wen Dai,3 Fen Li,4 Xiangting Li,3 Guoliang Yang,3 Lixin Liu,3 Xueying Chen2,3 1School of Medical Engineering, Jining Medical University, Jining, Shandong, People’s Republic of China; 2The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, and The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, People’s Republic of China; 3Department of Cardiology, Affiliated Hospital of Jining Medical University, Jining, Shandong, People’s Republic of China; 4Electrocardiogram Room, Jining First People’s Hospital, Jining, Shandong, People’s Republic of ChinaCorrespondence: Xueying Chen, Department of Cardiology, Affiliated Hospital of Jining Medical University, No. 89 Guhuai Road, Jining, 272029, Shandong, People’s Republic of China, Tel [phone], Fax [phone], Email [email protected]: Many studies have shown that glycated hemoglobin (HbA1c) is associated with coronary artery disease (CAD). HbA1c was independently related to angiographic severity in Chinese patients with CAD after adjusting for other covariates. Some traditional cardiovascular drugs may have an impact on this relationship.Methods: This retrospective study enrolled a total of 572 CAD patients who underwent their coronary angiography and had their HbA1c levels measured at the Chinese Hospital. The complexity of the coronary artery lesions was evaluated using the Syntax score, and the subjects were divided into 4 inter quartiles according to HbA1c levels. Covariates included history of traditional cardiovascular drugs.Results: The average age of selected participants was 61.00 ± 9.15 years old, and about 54.72% of them were male. Result of fully adjusted linear regression showed that HbA1c was positively associated with Syntax score after adjusting confounders (β = 1.09, 95% CI: 0.27, 1.91, P = 0.0096). By interaction and stratified analyses, the interactions were observed based on our specification including with the medication history of statins and angiotensin receptor blockers (ARBs) (P values for interaction < 0.05).Conclusion: In this study, we found a positive correlation between the HbA1c levels and the SYNTAX score among CAD individuals, and oral statins and ARBs medication could affect the correlation. Thus, HbA1c measurement could be used for the evaluation of the severity and complexity of coronary lesions among CAD patients.Keywords: HbA1c, SYNTAX score, coronary artery disease, statins, ARBs

Keywords

• hba1c
• syntax score
• coronary artery disease
• statins
• arbs