Journal of the Egyptian National Cancer Institute (Mar 2014)

Primary

  • Mahmoud Abbas,
  • Mario W. Kramer,
  • Tilmann Spieker,
  • Thomas R.W. Herrman,
  • Axel S. Merseburger,
  • Klaus-Michael Müller,
  • Marcus A. Kuczyk,
  • Jan U. Becker,
  • Hans-Heinrich Kreipe

DOI
https://doi.org/10.1016/j.jnci.2013.11.002
Journal volume & issue
Vol. 26, no. 1
pp. 51 – 54

Abstract

Read online

Primary epithelial tumor of the renal pelvis is rare and only 100 cases are reported in the literature [1]. Histological examination of the tumor showed glands, cysts, and papillae lined by pseudostratified columnar epithelium with hyperchromatic nuclei. Scattered signet ring-type cells were also seen floating in large pools of extracellular mucin. Sections from the ureter showed a component of adenocarcinoma in situ. No invasive tumor was identified in ureteric tissue. One case was reported with carcinoma in situ of the ureter (2). Immunohistochemically: The tumor showed positivity for CK7, CK20, CK8/18, GATA-3, MSH-2, MSH-6, MLH-1, Ber-EP4, and S-100-P with focal positivity for CDX-2, weak positivity for PMS-2 and negativity in TTF-1 and Her-2. Molecular pathological analysis revealed microsatellite stability and without mutation in K-ras-gene. Thus, a diagnosis of mucinous adenocarcinoma of the renal pelvis with in situ adenocarcinoma of the ureter was made.

Keywords