Frontiers in Immunology (Apr 2024)
Genetic causal relationship between immune diseases and migraine: a Mendelian randomization study
- Guanglu Li,
- Guanglu Li,
- Shaojie Duan,
- International Headache Genetics Consortium (IHGC),
- Tao Zheng,
- Tiantian Zhu,
- Baoquan Qu,
- Lei Liu,
- Zunjing Liu,
- Verneri Anttila,
- Ville Artto,
- Andrea C Belin,
- Anna Bjornsdottir,
- Gyda Bjornsdottir,
- Dorret I Boomsma,
- Sigrid Børte,
- Mona A Chalmer,
- Daniel I Chasman,
- Bru Cormand,
- Ester Cuenca-Leon,
- George Davey-Smith,
- Irene de Boer,
- Martin Dichgans,
- Tonu Esko,
- Tobias Freilinger,
- Padhraig Gormley,
- Lyn R Griffiths,
- Eija Hämäläinen,
- Thomas F Hansen,
- Aster VE Harder,
- Heidi Hautakangas,
- Marjo Hiekkala,
- Maria G Hrafnsdottir,
- M. Arfan Ikram,
- Marjo-Riitta Järvelin,
- Risto Kajanne,
- Mikko Kallela,
- Jaakko Kaprio,
- Mari Kaunisto,
- Lisette JA Kogelman,
- Espen S Kristoffersen,
- Christian Kubisch,
- Mitja Kurki,
- Tobias Kurth,
- Lenore Launer,
- Terho Lehtimäki,
- Davor Lessel,
- Lannie Ligthart,
- Sigurdur H Magnusson,
- Rainer Malik,
- Bertram Müller-Myhsok,
- Carrie Northover,
- Dale R Nyholt,
- Jes Olesen,
- Aarno Palotie,
- Priit Palta,
- Linda M Pedersen,
- Nancy Pedersen,
- Matti Pirinen,
- Danielle Posthuma,
- Patricia Pozo-Rosich,
- Alice Pressman,
- Olli Raitakari,
- Caroline Ran,
- Gudrun R Sigurdardottir,
- Hreinn Stefansson,
- Kari Stefansson,
- Olafur A Sveinsson,
- Gisela M Terwindt,
- Thorgeir E Thorgeirsson,
- Arn MJM vanden Maagdenberg,
- Cornelia van Duijn,
- Maija Wessman,
- Bendik S Winsvold,
- John-Anker Zwart.
Affiliations
- Guanglu Li
- Graduate School of Beijing University of Chinese Medicine, Beijing, China
- Guanglu Li
- Department of Neurology, China-Japan Friendship Hospital, Beijing, China
- Shaojie Duan
- Department of Geriatrics, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, China
- International Headache Genetics Consortium (IHGC)
- Tao Zheng
- Graduate School of Beijing University of Chinese Medicine, Beijing, China
- Tiantian Zhu
- Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Baoquan Qu
- Graduate School of Beijing University of Chinese Medicine, Beijing, China
- Lei Liu
- Department of Neurology, China-Japan Friendship Hospital, Beijing, China
- Zunjing Liu
- Department of Neurology, Peking University People’s Hospital, Beijing, China
- Verneri Anttila
- Ville Artto
- Andrea C Belin
- Anna Bjornsdottir
- Gyda Bjornsdottir
- Dorret I Boomsma
- Sigrid Børte
- Mona A Chalmer
- Daniel I Chasman
- Bru Cormand
- Ester Cuenca-Leon
- George Davey-Smith
- Irene de Boer
- Martin Dichgans
- Tonu Esko
- Tobias Freilinger
- Padhraig Gormley
- Lyn R Griffiths
- Eija Hämäläinen
- Thomas F Hansen
- Aster VE Harder
- Heidi Hautakangas
- Marjo Hiekkala
- Maria G Hrafnsdottir
- M. Arfan Ikram
- Marjo-Riitta Järvelin
- Risto Kajanne
- Mikko Kallela
- Jaakko Kaprio
- Mari Kaunisto
- Lisette JA Kogelman
- Espen S Kristoffersen
- Christian Kubisch
- Mitja Kurki
- Tobias Kurth
- Lenore Launer
- Terho Lehtimäki
- Davor Lessel
- Lannie Ligthart
- Sigurdur H Magnusson
- Rainer Malik
- Bertram Müller-Myhsok
- Carrie Northover
- Dale R Nyholt
- Jes Olesen
- Aarno Palotie
- Priit Palta
- Linda M Pedersen
- Nancy Pedersen
- Matti Pirinen
- Danielle Posthuma
- Patricia Pozo-Rosich
- Alice Pressman
- Olli Raitakari
- Caroline Ran
- Gudrun R Sigurdardottir
- Hreinn Stefansson
- Kari Stefansson
- Olafur A Sveinsson
- Gisela M Terwindt
- Thorgeir E Thorgeirsson
- Arn MJM vanden Maagdenberg
- Cornelia van Duijn
- Maija Wessman
- Bendik S Winsvold
- John-Anker Zwart.
- DOI
- https://doi.org/10.3389/fimmu.2024.1376698
- Journal volume & issue
-
Vol. 15
Abstract
BackgroundMigraine has an increased prevalence in several immune disorders, but genetic cause-effect relationships remain unclear. Mendelian randomization (MR) was used in this study to explore whether immune diseases are causally associated with migraine and its subtypes.MethodsWe conducted a two-sample bidirectional multivariate Mendelian randomization study. Single-nucleotide polymorphisms (SNP) for six immune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), type 1 diabetes mellitus (T1D), allergic rhinitis (AR), asthma and psoriasis, were used as genetic instrumental variables. Summary statistics for migraine were obtained from 3 databases: the International Headache Genetics Consortium (IHGC), UK Biobank, and FinnGen study. MR analyses were performed per outcome database for each exposure and subsequently meta-analyzed. Reverse MR analysis was performed to determine whether migraine were risk factors for immune diseases. In addition, we conducted a genetic correlation to identify shared genetic variants for these two associations.ResultsNo significant causal relationship was found between immune diseases and migraine and its subtypes. These results were robust with a series of sensitivity analyses. Using the linkage disequilibrium score regression method (LDSC), we detected no genetic correlation between migraine and immune diseases.ConclusionThe evidence from our study does not support a causal relationship between immune diseases and migraine. The mechanisms underlying the frequent comorbidity of migraine and several immune diseases need to be further elucidated.
Keywords
