Nature Communications (Mar 2019)
Microbial abundance, activity and population genomic profiling with mOTUs2
- Alessio Milanese,
- Daniel R Mende,
- Lucas Paoli,
- Guillem Salazar,
- Hans-Joachim Ruscheweyh,
- Miguelangel Cuenca,
- Pascal Hingamp,
- Renato Alves,
- Paul I Costea,
- Luis Pedro Coelho,
- Thomas S. B. Schmidt,
- Alexandre Almeida,
- Alex L Mitchell,
- Robert D. Finn,
- Jaime Huerta-Cepas,
- Peer Bork,
- Georg Zeller,
- Shinichi Sunagawa
Affiliations
- Alessio Milanese
- European Molecular Biology Laboratory
- Daniel R Mende
- Daniel K. Inouye Center for Microbial Oceanography Research and Education, University of Hawaiʻi at Mānoa
- Lucas Paoli
- Department of Biology, Institute of Microbiology and Swiss Institute of Bioinformatics, ETH Zürich
- Guillem Salazar
- Department of Biology, Institute of Microbiology and Swiss Institute of Bioinformatics, ETH Zürich
- Hans-Joachim Ruscheweyh
- Department of Biology, Institute of Microbiology and Swiss Institute of Bioinformatics, ETH Zürich
- Miguelangel Cuenca
- Department of Biology, Institute of Microbiology and Swiss Institute of Bioinformatics, ETH Zürich
- Pascal Hingamp
- Aix Marseille Univ, Université de Toulon, CNRS, IRD, MIO UM 110
- Renato Alves
- European Molecular Biology Laboratory
- Paul I Costea
- European Molecular Biology Laboratory
- Luis Pedro Coelho
- European Molecular Biology Laboratory
- Thomas S. B. Schmidt
- European Molecular Biology Laboratory
- Alexandre Almeida
- European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus
- Alex L Mitchell
- European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus
- Robert D. Finn
- European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus
- Jaime Huerta-Cepas
- European Molecular Biology Laboratory
- Peer Bork
- European Molecular Biology Laboratory
- Georg Zeller
- European Molecular Biology Laboratory
- Shinichi Sunagawa
- Department of Biology, Institute of Microbiology and Swiss Institute of Bioinformatics, ETH Zürich
- DOI
- https://doi.org/10.1038/s41467-019-08844-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Metagenomic analysis based on universal phylogenetic marker gene (MG)-based operational taxonomic units (mOTUs) is a useful strategy, especially for microbial species without reference genomes. Here, the authors develop mOTUs2, an updated and functionally extended profiling tool for microbial abundance, activity and population profiling.
